NIPBL, Polyclonal Antibody

Anti -NIPBL (Nipped-B-like Protein, Delangin, SCC2 Homolog, IDN3)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 5; NC_000005.9 (36876861..37065926). Location: 5p13.2

Polyclonal

Goat

Recognizes mouse NIPBL. Species sequence homology: Bovine, canine, human and rat.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-NIPBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex.

Antibodies; Abs to Proteins

ELISA (EL/EIA), Immunohistochemistry (IHC)

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:32,000
Immunohistochemistry: Paraffin

316,051 Da[Similar Products]

Nipped-B homolog (Drosophila)

nipped-B-like protein; delangin; SCC2 homolog; sister chromatid cohesion 2 homolog

Nipped-B-like protein

IDN3  [Similar Products]

NIPBL_HUMAN

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NIPBL: a chromatin protein involved in sister chromatid cohesion. Interacts directly with CBX5 via the PxVxL motif, which is required for interaction with chromoshadow domains. Defects in NIPBL are the cause of Cornelia de Lange syndrome (CDL). CDL is a dominantly inherited multisystem developmental disorder. Three alternatively spliced isoforms have been reported.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: nucleoplasm; nucleus; chromatin

Molecular Function: protein C-terminus binding; protein binding; histone deacetylase binding; protein N-terminus binding; chromatin binding

Biological Process: heart morphogenesis; embryonic forelimb morphogenesis; fat cell differentiation; developmental growth; regulation of embryonic development; mitotic sister chromatid cohesion; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; ear morphogenesis; forelimb morphogenesis; positive regulation of histone deacetylation; sensory perception of sound; embryonic digestive tract morphogenesis; regulation of hair cycle; eye morphogenesis; regulation of developmental growth; external genitalia morphogenesis; stem cell maintenance; embryonic viscerocranium morphogenesis; positive regulation of ossification; maintenance of mitotic sister chromatid cohesion; positive regulation of transcription from RNA polymerase II promoter; brain development; mitotic cell cycle; negative regulation of transcription, DNA-dependent; cognition; response to DNA damage stimulus; metanephros development

Disease: Cornelia De Lange Syndrome 1

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