CIZ1, Polyclonal Antibody

CIZ1; CDKN1A interacting zinc finger protein 1; LSFR1; NP94; ZNF356; CDKN1A-interacting zinc finger protein 1; cip1-interacting zinc finger protein; nuclear protein NP94; zinc finger protein 356; CIZ1 antibody; CDKN1A interacting zinc finger protein 1 antibody; LSFR1 antibody; NP94 antibody; ZNF356 antibody; CDKN1A-interacting zinc finger protein 1 antibody; cip1-interacting zinc finger protein antibody; nuclear protein NP94 antibody; zinc finger protein 356 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-CIZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 90kDa band observed in nuclear lysates of cell line HeLa (calculated MW of 91.2kDa according to NP_001124490.1). Recommended concentration: 0.3-1ug/ml.

(0.3ug/ml) staining of HeLa nuclear lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

88,520 Da

CDKN1A interacting zinc finger protein 1

cip1-interacting zinc finger protein

Cip1-interacting zinc finger protein

LSFR1; NP94; ZNF356  [Similar Products]

CIZ1_HUMAN

The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CIZ1: May regulate the subcellular localization of CIP/WAF1. Defects in CIZ1 may be a cause of ***** onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: nucleus

Molecular Function: nucleic acid binding; protein binding; zinc ion binding

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