Product Name
Coagulation Factor XIIa (RFXIIA), Recombinant Protein
Full Product Name
Recombinant Rat Coagulation Factor XIIa
Product Synonym Names
Rat Factor XIIa, Rat Proteins
Product Gene Name
RFXIIA recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for D3ZTE0
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen Liquid
Concentration
0.25 mg/ml (lot specific)
Extinction Coefficient
1.73
Buffer
4 mM Sodium Acetate; 0.15 M NaCl; pH 5.3
Preparation and Storage
Store at -70 degree C.
Other Notes
Small volumes of RFXIIA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RFXIIA recombinant protein
Rat Factor alpha-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system of blood coagulation. Recombinant insect cell derived rat Factor alpha-XIIa is manufactured by activation of recombinant rat Factor XII with human kallikrein followed by removal of the activator. >95percent activation is observed on SDS-PAGE. The protein purity is determined by SDS-PAGE and activity is determined via complementation in an APTT clotting assay using Factor XII immuno-deficient human plasma. Custom mutants of Factor XII are also available, please contact us for more details.
Product Categories/Family for RFXIIA recombinant protein
FACTOR XII
NCBI/Uniprot data below describe general gene information for RFXIIA. It may not necessarily be applicable to this product.
NCBI Accession #
D3ZTE0.1
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UniProt Primary Accession #
D3ZTE0
[Other Products]
UniProt Secondary Accession #
Q5M879[Other Products]
UniProt Related Accession #
D3ZTE0[Other Products]
Molecular Weight
75,000 (Approximate)
NCBI Official Full Name
Coagulation factor XII
NCBI Official Synonym Full Names
coagulation factor XII
NCBI Official Symbol
F12 [Similar Products]
NCBI Official Synonym Symbols
HAF
[Similar Products]
NCBI Protein Information
coagulation factor XII
UniProt Protein Name
Coagulation factor XII
UniProt Synonym Protein Names
Hageman factor; HAF
UniProt Gene Name
F12 [Similar Products]
UniProt Synonym Gene Names
HAF [Similar Products]
UniProt Comments for RFXIIA
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa ().
Research Articles on RFXIIA
1. FXIIa-kininogen mediated vasoconstriction contributes significantly to CKD hypertension in Brown Norway rats.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
