SLC34A3, Polyclonal Antibody

HHRH; NPTIIc

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity purification

0.5mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-SLC34A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:25-1:100

Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using SLC34A3 Polyclonal Antibody at dilution 1:20

63,550 Da

solute carrier family 34 (type II sodium/phosphate cotransporter), member 3

sodium-dependent phosphate transport protein 2C; Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; naPi-2c; sodium-phosphate transport protein 2C; sodium/inorganic phosphate cotransporter IIC; solute carrier family 34 (sodium phosphate), member 3; type IIc Na+/Pi cotransporter

Sodium-dependent phosphate transport protein 2C

NPT2C; NPTIIC; Sodium-phosphate transport protein 2C; Na(+)/Pi cotransporter 2C; NaPi-2c  [Similar Products]

NPT2C_HUMAN

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]

SLC34A3: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH). HHRH is an autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion. Belongs to the SLC34A transporter family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: brush border membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: sodium:phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity

Biological Process: cellular phosphate ion homeostasis; phosphate transport; sodium ion transport; ion transport; transmembrane transport

Disease: Hypophosphatemic Rickets With Hypercalciuria, Hereditary

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