Antithrombin III, Polyclonal Antibody

Sheep Antibody to Human Antithrombin III

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (173872942..173886516, complement). Location: 1q23-q25.1

Polyclonal

Sheep

Antithrombin III
Antithrombin III (ATH III) is a plasma protein synthesized in the liver. Normal plasma levels are 115-160mg/L. ATH III consists of a single polypeptide chain and has a molecular weight of 58kDa. ATH III is a serine protease inhibitor a

Antiserum is delipidated and if necessary adsorbed to monospecificity by use of solid-phase adsorbants. Following adsorption an immunoglobulin fraction is produced by ion-exchange chromatography (DEAE). Monospecificity is confirmed by immunoelectrophoresi

Purified, Liquid

11.0mg/ml (OD280nm, E^1% = 14.5) (lot specific)

Store at 2 to 8 degree C. Slight precipitation can occur upon storage that can be removed by centrifugation and should not affect performance characteristics.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-SERPINC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Polyclonal Antibodies to Platelets and Hemostasis Antigens

52,602 Da[Similar Products]

serpin peptidase inhibitor, clade C (antithrombin), member 1

antithrombin-III; serpin C1; antithrombin III; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1

Antithrombin-III

AT3  [Similar Products]

ANT3_HUMAN

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq]

Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Found in plasma. Ref.21

Post-translational modification: Phosphorylation sites are present in the extracelllular medium.

Involvement in disease: Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [

MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Ref.3 Ref.12 Ref.13 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.59 Ref.60 Ref.61 Ref.62 Ref.63 Ref.64 Ref.65 Ref.66

Sequence similarities: Belongs to the serpin family.

Mass spectrometry: Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. Ref.13Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414. Ref.13

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