ACACA, Blocking Peptide

Acetyl-CoA carboxylase 1; ACC1; ACC-alpha; Biotin carboxylase; ACACA; ACAC; ACC1; ACCA

For Research Use Only. Not for use in diagnostic procedures.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of ACACA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

269,999 Da

acetyl-CoA carboxylase alpha

acetyl-CoA carboxylase 1

Acetyl-CoA carboxylase 1

ACAC; ACC1; ACCA; ACC1  [Similar Products]

ACACA_HUMAN

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Lipid Metabolism - fatty acid biosynthesis; Carbohydrate Metabolism - propanoate; Ligase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; nucleolus

Molecular Function: acetyl-CoA carboxylase activity; protein binding

Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; fatty acid biosynthetic process; positive regulation of cellular metabolic process; protein homotetramerization

Disease: Acetyl-coa Carboxylase Deficiency

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