Product Name
ACC alpha (ACACA), Blocking Peptide
Full Product Name
ACC alpha (pS80) Blocking Peptide
Product Synonym Names
ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha
Product Gene Name
ACACA blocking peptide
[Similar Products]
ACC alpha peptide (MBS8244131) is used for blocking the activity of ACC alpha antibody (MBS8241730)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13085
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Sheep
Form/Format
Lyophilized Powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of ACACA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACACA blocking peptide
The peptide is used to block Anti-ACC alpha reactivity.
Applications Tested/Suitable for ACACA blocking peptide
Blocking (BL)
Application Notes for ACACA blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.
NCBI Accession #
Q13085.2
[Other Products]
UniProt Primary Accession #
Q13085
[Other Products]
UniProt Secondary Accession #
Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3; B2RP68[Other Products]
UniProt Related Accession #
Q13085[Other Products]
Molecular Weight
269,999 Da
NCBI Official Full Name
Acetyl-CoA carboxylase 1
NCBI Official Synonym Full Names
acetyl-CoA carboxylase alpha
NCBI Official Symbol
ACACA [Similar Products]
NCBI Official Synonym Symbols
ACC; ACAC; ACC1; ACCA; ACACAD
[Similar Products]
NCBI Protein Information
acetyl-CoA carboxylase 1
UniProt Protein Name
Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names
ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14
UniProt Gene Name
ACACA [Similar Products]
UniProt Synonym Gene Names
ACAC; ACC1; ACCA; ACC1 [Similar Products]
UniProt Entry Name
ACACA_HUMAN
NCBI Summary for ACACA
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACACA
ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.
Protein type: EC 6.4.1.2; EC 6.3.4.14; Lipid Metabolism - fatty acid biosynthesis; Carbohydrate Metabolism - pyruvate; Ligase; Carbohydrate Metabolism - propanoate
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: actin cytoskeleton; cytoplasm; cytosol; mitochondrion; nucleolus
Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; metal ion binding; protein binding
Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; cellular lipid metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid homeostasis; multicellular organismal protein metabolic process; positive regulation of cellular metabolic process; protein homotetramerization; tissue homeostasis; triacylglycerol biosynthetic process; vitamin metabolic process; water-soluble vitamin metabolic process
Disease: Acetyl-coa Carboxylase Deficiency
Research Articles on ACACA
1. Phospho-acetyl-CoA carboxylase protein expression correlates with tumor grade and the disease stage in gastric cancer.
Precautions
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Disclaimer
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