Product Name
Atlastin-1 (Atl1), Recombinant Protein
Full Product Name
Recombinant Mouse Atlastin-1 (Atl1)
Product Gene Name
Atl1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Spg3a[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-558aa; full length protein
Sequence
MAKSRRDRNS WGGFSEKSSD WSSEEEEPVR KAGPVQVLIV KDDHSFELDE AALNRILLSQ AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV GDYNEPLTGF SWRGGSERET TGIQIWSEVF LINKLDGKKV AVLLMDTQGT FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ NVQEDDLQHL QLFTEYGRLA MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL KVSGNQHEEL QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL IPWLLSPERL DIKEINGNKI TCRGLLEYFK AYIKIYQGEE LPHPKSMLQA TAEANNLAAV ATAKDTYNKK MEEVCGGDKP FLAPNDLQSK HLQLKEESVK LFRGVKKMGG EEFSRRYLQQ LESEIDELYI QYIKHNDSKN IFHAARTPAT LFVVIFITYV IAGVTGFIGL DIIASLCNMI MGLTLITLCT WAYIRYSGEY RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLCHQ AFPAPKSEPT QQPEKKKI
3D Structure
ModBase 3D Structure for Q8BH66
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Atl1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Atl1 recombinant protein
Transmembrane Protein
Application Notes for Atl1 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Atl1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_848743.1
[Other Products]
NCBI GenBank Nucleotide #
NM_178628.5
[Other Products]
UniProt Primary Accession #
Q8BH66
[Other Products]
UniProt Secondary Accession #
Q8BJH5[Other Products]
UniProt Related Accession #
Q8BH66[Other Products]
Molecular Weight
63,377 Da
NCBI Official Full Name
atlastin-1
NCBI Official Synonym Full Names
atlastin GTPase 1
NCBI Official Symbol
Atl1 [Similar Products]
NCBI Official Synonym Symbols
Fsp1; Spg3; Adfsp; Spg3a; 4930435M24Rik
[Similar Products]
NCBI Protein Information
atlastin-1
UniProt Protein Name
Atlastin-1
UniProt Synonym Protein Names
Spastic paraplegia 3A homolog
UniProt Gene Name
Atl1 [Similar Products]
UniProt Synonym Gene Names
Spg3a [Similar Products]
UniProt Entry Name
ATLA1_MOUSE
NCBI Summary for Atl1
This gene encodes a member of the dynamin family of GTPases. The encoded protein interacts with tubule-shaping proteins of the endoplasmic reticulum. Mutations in the homologous human gene can cause hereditary spastic paraplegia. [provided by RefSeq, Feb 2010]
UniProt Comments for Atl1
atlastin: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3); also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in ATL1 are the cause of hereditary sensory neuropathy type 1D (HSN1D). HSN1D is a disease characterized by *****-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Belongs to the GBP family. Atlastin subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 3.6.5.-; Vesicle
Cellular Component: cell projection; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi cis cisterna; integral to membrane; membrane
Molecular Function: GTP binding; GTPase activity; hydrolase activity; identical protein binding; nucleotide binding
Biological Process: axonogenesis; endoplasmic reticulum organization and biogenesis; protein homooligomerization
Research Articles on Atl1
1. This publication discusses functional and mutational aspects of atlastin GTPase 1 in humans.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
