Full Product Name
ACTHR Antibody
Product Synonym Names
ACTH receptor; ACTH-R; ACTHR; adrenocorticotropic hormone receptor; adrenocorticotropin receptor; MC2-R; melanocortin-2 receptor
Product Gene Name
anti-ACTHR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q01718
Species Reactivity
Human, Mouse
Specificity
ACTHR antibody detects endogenous levels of total ACTHR protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human ACTHR.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ACTHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ACTHR antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-ACTHR antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-ACTHR antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:20000
Testing Data of anti-ACTHR antibody
Western Blot (WB) of anti-ACTHR antibody
Peptide-+ Western blot analysis of extracts from HeLa cells, using ACTHR antibody. Immunofluorescence analysis of MCF-7 cells, using ACTHR antibody.
NCBI/Uniprot data below describe general gene information for ACTHR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000520.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000529.2
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UniProt Primary Accession #
Q01718
[Other Products]
UniProt Secondary Accession #
Q3MI45; Q504X6; A8K016[Other Products]
UniProt Related Accession #
Q01718[Other Products]
Molecular Weight
33,927 Da
NCBI Official Full Name
adrenocorticotropic hormone receptor
NCBI Official Synonym Full Names
melanocortin 2 receptor
NCBI Official Symbol
MC2R [Similar Products]
NCBI Official Synonym Symbols
ACTHR
[Similar Products]
NCBI Protein Information
adrenocorticotropic hormone receptor
UniProt Protein Name
Adrenocorticotropic hormone receptor
UniProt Synonym Protein Names
Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R
UniProt Gene Name
MC2R [Similar Products]
UniProt Synonym Gene Names
ACTHR; ACTH receptor; ACTH-R; MC2-R [Similar Products]
NCBI Summary for ACTHR
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
UniProt Comments for ACTHR
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Product References and Citations for anti-ACTHR antibody
Mountjoy K.G., Science 257:1248-1251(1992). Gantz I., J. Biol. Chem. 268:8246-8250(1993). Metherell L.A., Nat. Genet. 37:166-170(2005).
Research Articles on ACTHR
1. Results show regulation of melanocortin receptors MC2R, MC3R and MC4R gene expressions in CD8(+) cytotoxic T-lymphocytes and CD19(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha) inhibitor adalimumab.
Precautions
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Disclaimer
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