Product Name
HABP2 , Polyclonal Antibody
Full Product Name
HABP2 Polyclonal Antibody
Product Synonym Names
FSAP; HABP; PHBP; HGFAL
Product Gene Name
anti-HABP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human HABP2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-HABP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HABP2 antibody
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-HABP2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-HABP2 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100
Western Blot (WB) of anti-HABP2 antibody
Western blot analysis of extracts of various cell lines, using HABP2 antibody.
NCBI/Uniprot data below describe general gene information for HABP2 . It may not necessarily be applicable to this product.
NCBI Accession #
NP_001171131.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001177660.2
[Other Products]
UniProt Secondary Accession #
O00663; A8K467; B7Z8U5; F5H5M6[Other Products]
UniProt Related Accession #
Q14520[Other Products]
Molecular Weight
Calculated MW: 62kDa
NCBI Official Full Name
hyaluronan-binding protein 2 isoform 2
NCBI Official Synonym Full Names
hyaluronan binding protein 2
NCBI Official Symbol
HABP2 [Similar Products]
NCBI Official Synonym Symbols
FSAP; HABP; PHBP; HGFAL; NMTC5
[Similar Products]
NCBI Protein Information
hyaluronan-binding protein 2
UniProt Protein Name
Hyaluronan-binding protein 2
UniProt Synonym Protein Names
Factor VII-activating protease; Factor seven-activating protease; FSAP
UniProt Gene Name
HABP2 [Similar Products]
UniProt Synonym Gene Names
HGFAL; PHBP; FSAP [Similar Products]
UniProt Entry Name
HABP2_HUMAN
NCBI Summary for HABP2
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
UniProt Comments for HABP2
HABP2: Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. Belongs to the peptidase S1 family.
Protein type: Secreted, signal peptide; Cell adhesion; Protease; Motility/polarity/chemotaxis; EC 3.4.21.-; Secreted
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: extracellular region; extracellular space
Molecular Function: glycosaminoglycan binding; serine-type endopeptidase activity
Biological Process: cell adhesion; proteolysis
Disease: Thrombophilia Due To Thrombin Defect; Thyroid Cancer, Nonmedullary, 5
Research Articles on HABP2
1. Patients with Gram-negative sepsis caused by B. pseudomallei have abundant FSAP activation, which significantly correlates with stage of disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
