Product Name
Arg3.1 (ARC), Polyclonal Antibody
Full Product Name
Arg3.1 (Activity-regulated Cytoskeleton-associated Protein, Activity-regulated Gene 3.1 Protein Homolog, ARG3.1/ARC, ARC/ARG3.1)
Product Synonym Names
Anti -Arg3.1 (Activity-regulated Cytoskeleton-associated Protein, Activity-regulated Gene 3.1 Protein Homolog, ARG3.1/ARC, ARC/ARG3.1)
Product Gene Name
anti-ARC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 8; NC_000008.10 (143692410..143695833, complement). Location: 8q24.3
3D Structure
ModBase 3D Structure for Q7LC44
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human Arg3.1. Species Crossreactivity: rat and mouse
Purity/Purification
Serum
Serum
Form/Format
Supplied as a lyophilized powder. Reconstitute with 100ul of sterile ddH2O.
Immunogen
Synthetic peptide corresponding to the C-terminal of human Arg3.1 protein, conjugated to Blue Carrier Protein.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ARC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARC antibody
Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. Arg3.1 expression is detectable in neuronal cell bodies and dendrites in the brain regions including striatum and cortex hippocampus, hypothalamus, amygdala.
Product Categories/Family for anti-ARC antibody
Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-ARC antibody
Immunohistochemistry (IHC)
Application Notes for anti-ARC antibody
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry: 1:50-1:1000
NCBI/Uniprot data below describe general gene information for ARC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_056008.1
[Other Products]
NCBI GenBank Nucleotide #
NM_015193.3
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UniProt Primary Accession #
Q7LC44
[Other Products]
UniProt Secondary Accession #
Q9UJW6; Q9Y469[Other Products]
UniProt Related Accession #
Q7LC44[Other Products]
Molecular Weight
45,316 Da[Similar Products]
NCBI Official Full Name
activity-regulated cytoskeleton-associated protein
NCBI Official Synonym Full Names
activity-regulated cytoskeleton-associated protein
NCBI Official Symbol
ARC [Similar Products]
NCBI Official Synonym Symbols
Arg3.1; KIAA0278
[Similar Products]
NCBI Protein Information
activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; OTTHUMP00000165993; activity-regulated gene 3.1 protein homolog
UniProt Protein Name
Activity-regulated cytoskeleton-associated protein
UniProt Synonym Protein Names
ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog
Protein Family
AAA ATPase forming ring-shaped complexes
UniProt Gene Name
ARC [Similar Products]
UniProt Synonym Gene Names
KIAA0278 [Similar Products]
UniProt Entry Name
ARC_HUMAN
UniProt Comments for ARC
ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family.
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: postsynaptic membrane; postsynaptic density; cytoplasm; acrosome; plasma membrane; dendritic spine; cell junction; endosome; actin cytoskeleton
Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; endocytosis; cytoskeleton organization and biogenesis; learning; endoderm development; regulation of neuronal synaptic plasticity
Research Articles on ARC
1. Arc/MS2 mRNA assembles into particles that move independently, bidirectionally, and intermittently. These observations identify several phases of Arc mRNA movement that serve as potential points for regulating Arc mRNA localization.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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