Full Product Name
ASIC2 Antibody FITC
Product Synonym Names
FITC-Conjugated Acid-sensing ion channel 2 Antibody; ACCN1 antibody; Acid sensing ion channel 2 antibody; Amiloride sensitive brain sodium channel antibody; Amiloride sensitive cation channel 1 neuronal antibody; ASIC2 antibody; BNaC1 antibody; Brain sodium channel 1 antibody; Degenerin antibody; Mammalian degenerin homolog antibody; MDEG antibody; Neuronal amiloride sensitive cation channel 1 antibody
Product Gene Name
anti-ASIC2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16515
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein.
Molecular Function
acid-sensing ion channel activity; ion gated channel activity; ligand-gated sodium channel activity
Subcellular Location
Cell Membrane; Multi-pass membrane protein
Preparation and Storage
Store at -20 degree C for long term storage.
Other Notes
Small volumes of anti-ASIC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASIC2 antibody
Overview: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Structure: Homotrimer or heterotrimer with other ASIC proteins.
Expression: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
Applications Tested/Suitable for anti-ASIC2 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-ASIC2 antibody
ELISA: 1:50,000
IP: 1:200
WB: 1:2,500-1:5,000
NCBI/Uniprot data below describe general gene information for ASIC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001085.2
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NCBI GenBank Nucleotide #
NM_001094.4
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UniProt Primary Accession #
Q16515
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UniProt Secondary Accession #
Q13553; Q6DJU1; Q8N3E2; E9PBX2[Other Products]
UniProt Related Accession #
Q16515[Other Products]
Molecular Weight
62,887 Da
NCBI Official Full Name
acid-sensing ion channel 2 isoform MDEG1
NCBI Official Synonym Full Names
acid sensing ion channel subunit 2
NCBI Official Symbol
ASIC2 [Similar Products]
NCBI Official Synonym Symbols
ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1
[Similar Products]
NCBI Protein Information
acid-sensing ion channel 2
UniProt Protein Name
Acid-sensing ion channel 2
UniProt Synonym Protein Names
Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1
Protein Family
Acid-sensing ion channel
UniProt Gene Name
ASIC2 [Similar Products]
UniProt Synonym Gene Names
ACCN; ACCN1; BNAC1; MDEG; MDEG [Similar Products]
NCBI Summary for ASIC2
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
UniProt Comments for ASIC2
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.MiscellaneousInhibited by anti-inflammatory drugs like salicylic acid (). Regulated by Zn2+.
Research Articles on ASIC2
1. Study shows that ASIC2 promotes metastasis of colorectal cancer (CRC) cells by activating the calcineurin/NFAT1 pathway under acidosis and high expression of ASIC2 predicts poor outcomes of patients with CRC.
Precautions
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Disclaimer
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