Product Name
COG4, cDNA Clone
Full Product Name
COG4 cDNA Clone
Product Gene Name
COG4 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggtgctgg ggacagacat gagtgatcgg agagctgcag tcatctttgc agatacactt actcttctgt ttgaagggat tgcccgcatt gtggagaccc accagccaat agtggagacc tattatgggc cagggagact ctataccctg atcaaatatc tgcaggtgga atgtgacaga caggtggaga aggtggtaga caagttcatc aagcaaaggg actaccacca gcagttccgg catgttcaga acaacctgat gagaaattct acaacagaaa aaatcgaacc aagagaactg gaccccatcc tgactgaggt caccctgatg aatgcccgca gtgagctata cttacgcttc ctcaagaaga ggattagctc tgattttgag gtgggagact ccatggcctc agaggaagta aagcaagagc accagaagtg tctggacaaa ctcctcaata actgcctttt gagctgtacc atgcaggagc taattggctt atatgttacc atggaggagt acttcatgag ggagactgtc aataaggctg tggctctgga cacctatgag aagggccagc tgacatccag catggtggat gatgtcttct acattgttaa gaagtgcatt gggcgggctc tgtccagctc cagcattgac tgtctctgtg ccatgatcaa cctcgccacc acagagctgg agtctgactt cagggatgtt ctgtgtaata agctgcggat gggctttcct gccaccacct tccaggacat ccagcgcggg gtgacaagtg ccgtgaacat catgcacagc agcctccagc aaggcaaatt tgacacaaaa ggcatcgaga gtactgacga ggcgaagatg tccttcctgg tgactctgaa caacgtggaa gtctgcagtg aaaacatctc cactctgaag aagacactgg agagtgactg caccaagctc ttcagccagg gcattggagg ggagcaggcc caggccaagt ttgacagctg cctttctgac ttggccgccg tgtccaacaa attccgagac ctcttgcagg aagggctgac ggagctcaac agcacagcca tcaagccaca ggtgcagcct tggatcaaca gctttttctc cgtctcccac aacatcgagg aggaagaatt caatgactat gaggccaacg acccttgggt acaacagttc atccttaacc tggagcagca aatggcagag ttcaaggcca gcctgtcccc ggtcatctac gacagcctaa ccggcctcat gactagcctt gttgccgtcg agttggagaa agtggtgctg aaatccacct ttaaccggct gggtggtctg cagtttgaca aggagctgag gtcactcatt gcctacctta ccacggtgac cacctggacc atccgagaca agtttgcccg gctctcccag atggccacca tcctcaatct ggagcgggtg accgagatcc tcgattactg gggacccaat tccggcccat tgacgtggcg cctcacccct gctgaagtgc gccaggtgct ggccctgcgg atagacttcc gcagtgaaga tatcaagagg ctgcgcctgt ag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of COG4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for COG4. It may not necessarily be applicable to this product.
NCBI Accession #
BC013347
[Other Products]
UniProt Secondary Accession #
Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9Y3W3; B4DMN8; C9JS23[Other Products]
UniProt Related Accession #
Q9H9E3[Other Products]
Molecular Weight
81,098 Da
NCBI Official Full Name
Homo sapiens component of oligomeric golgi complex 4, mRNA
NCBI Official Synonym Full Names
component of oligomeric golgi complex 4
NCBI Official Symbol
COG4 [Similar Products]
NCBI Official Synonym Symbols
COD1; CDG2J
[Similar Products]
NCBI Protein Information
conserved oligomeric Golgi complex subunit 4
UniProt Protein Name
Conserved oligomeric Golgi complex subunit 4
UniProt Synonym Protein Names
Component of oligomeric Golgi complex 4
Protein Family
Conserved oligomeric Golgi complex
UniProt Gene Name
COG4 [Similar Products]
UniProt Synonym Gene Names
COG complex subunit 4 [Similar Products]
UniProt Entry Name
COG4_HUMAN
NCBI Summary for COG4
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
UniProt Comments for COG4
COG4: Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Defects in COG4 are the cause of congenital disorder of glycosylation type 2J (CDG2J). It is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: Golgi membrane; Golgi transport complex; trans-Golgi network membrane
Molecular Function: protein binding
Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; Golgi vesicle prefusion complex stabilization; retrograde transport, vesicle recycling within Golgi; retrograde vesicle-mediated transport, Golgi to ER
Disease: Congenital Disorder Of Glycosylation, Type Iij
Research Articles on COG4
1. A novel R729W missense mutation in COG4 was associated with the congenital disorder of glycosylation type II.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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