Full Product Name
HESX1 Antibody
Product Synonym Names
ANF; MGC138294; RPX
Product Gene Name
anti-HESX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of HESX1
Calculated Molecular Weight: 185aa; 21kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15121 / sc-15122
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-HESX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HESX1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-HESX1 antibody
IHC: 1:20-1:200
NCBI/Uniprot data below describe general gene information for HESX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003856.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003865.2
[Other Products]
UniProt Secondary Accession #
Q52LC5; Q99667[Other Products]
UniProt Related Accession #
Q9UBX0[Other Products]
Molecular Weight
21,409 Da
NCBI Official Full Name
homeobox expressed in ES cells 1
NCBI Official Synonym Full Names
HESX homeobox 1
NCBI Official Symbol
HESX1 [Similar Products]
NCBI Official Synonym Symbols
ANF; RPX; CPHD5
[Similar Products]
NCBI Protein Information
homeobox expressed in ES cells 1; Rathke pouch homeobox; hAnf; homeobox protein ANF
UniProt Protein Name
Homeobox expressed in ES cells 1
UniProt Synonym Protein Names
Homeobox protein ANF; hAnf
Protein Family
Homeobox expressed in ES cells
UniProt Gene Name
HESX1 [Similar Products]
UniProt Synonym Gene Names
HANF; hAnf [Similar Products]
UniProt Entry Name
HESX1_HUMAN
NCBI Summary for HESX1
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for HESX1
HESX1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. Defects in HESX1 are a cause of septooptic dysplasia (SOD); also known as de Morsier syndrome. SOD is a rare autosomal recessive disease. SOD is characterized by optic nerve hypoplasia, absence of the corpus callosum and hypoplasia of the pituitary gland with panhypopopituitarism. Defects in HESX1 are a cause of growth hormone deficiency with pituitary anomalies (GHDPA). Defects in HESX1 are the cause of pituitary hormone deficiency combined type 5 (CPHD5). This disorder is manifested by deficiencies in anterior pituitary tropic hormones. week-old embryo. Belongs to the ANF homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: nucleus
Molecular Function: protein C-terminus binding; protein binding; DNA binding; sequence-specific DNA binding; protein N-terminus binding; chromatin binding
Biological Process: transcription, DNA-dependent; brain development; negative regulation of transcription, DNA-dependent; forebrain morphogenesis; otic vesicle formation; nose development
Disease: Septooptic Dysplasia
Research Articles on HESX1
1. Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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