Product Name
STIL, cDNA Clone
Full Product Name
STIL cDNA Clone
Product Gene Name
STIL cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggagccta tatatccttt tgcacggccc cagatgaata ccaggtttcc ttcaagcagg atggtacctt tccactttcc tccatcaaaa tgtgcacttt ggaacccaac gccaactgga gatttcatct acttacatct cagttactac agaaatccaa agcttgtggt gactgagaag accatccgac ttgcttatcg tcatgctaag cagaataaaa aaaattcgtc atgcttttta cttggttctc tgacagcaga cgaagatgaa gaaggtgtaa cattgacagt agatcgcttt gatcctggtc gagaagtacc tgaatgccta gaaataaccc ctactgcttc tcttcctggg gactttttga ttccatgcaa agttcatact caagaacttt gttcaagaga aatgatagtt cacagtgtag atgacttcag ttcagcttta aaggctctac agtgccatat atgtagcaaa gattccttgg actgtggtaa gctgctttcc ctaagagttc atatcacttc cagggagagt ttggacagtg tggaatttga cttgcattgg gcagcagtaa ctctagcaaa taactttaaa tgcacacctg tgaagcccat ccccattatt ccaacagctc tggcaagaaa cttgagcagt aatctgaata tttctcaagt tcaagggact tataaatatg gatatcttac catggatgaa acacgcaaat tgttactttt gttggaatct gatcccaagg tttattctct accattggtg ggaatttggc tgtctggaat tacacatatc tatagtcctc aggtatgggc ttgctgtttg cgatacatat tcaattcttc tgttcaagaa agggtttttt cagaatctgg aaatttcatc atagttctct attctatgac acataaggaa cctgagtttt atgaatgctt cccttgtgat ggcaagatac ctgactttcg gtttcagttg ctaaccagta aggaaacatt acatcttttc aaaaatgttg aacctcctga caaaaatcca atccgttgtg aactgagcgc tgaaagccaa aatgcagaaa cagagttttt cagtaaggct tccaagaatt tttcaattaa gaggtcttcc caaaagttat cttctgggaa gatgccaata catgatcacg actctggtgt tgaagatgaa gatttttctc caagaccaat tcctagtcct catccagtga gtcagaagat ttctaagatc caaccatcag ttcctgaact ttcacttgtg ttggatggca atttcataga atcaaaccct ctgcctactc cattggaaat ggtgaataat gaaaatcctc ctttgattaa ccacttggaa cacttgaagc cattgcaacc ccagctttat gatgagaaac acagtccaga agttgaagct ggagagcctt ccttgagagg aataccaaat cagttaaacc aggataaacc agctcttttg agacactgca aagtaagaca gccacctgcc tataagaaag ggaaccccca taccaggaac agtattaaac catcttctca taatgggcca tctcatgata tatttgaaaa gctccaaaca gtttctgctg gaaatgtaca aaacgaagag tatcctataa gaccctccac acttaattct aggcagtctt ctcttgcccc gcagtcccaa ccacacgatt ttgttttttc accccataat tcaggaagac caatggaact tcagatacct actcccccac tgccatctta ctgttccaca aacgtttgca ggtgttgtca gcatcatagt catattcaat atagtccgct aaattcttgg caaggagcaa acacagttgg atccattcaa gatgtccagt ctgaagccct tcaaaagcat tcattatttc acccaagtgg atgtccagcc ctgtactgta atgcattctg ttcttcaagt agtcctatag ccttgagacc tcagggagat atgggcagtt gttctcccca cagcaatatt gaaccatcgc ctgtggcaag accgccttca catatggact tatgtaaccc acagccttgc acagtgtgca tgcacacacc caagactgag tcagataatg gaatgatggg actatctcca gatgcatatc ggttcctcac agaacaagac agacagctaa gactacttca ggcacagatt cagcgtttgt tggaagcaca gtctctgatg ccctgttccc ctaagacaac tgctgttgaa gacacagtgc aagctggaag acaaatggag ttggtttctg tggaagcaca gtcttcccct ggcttgcaca tgagaaaagg tgtaagcatt gctgtgagca caggtgctag cttgttttgg aatgcagcag gtgaggatca agagcctgac tctcaaatga agcaagatga taccaaaatt tccagtgagg acatgaattt ttctgtcgat attaataatg aagtcacaag tcttccaggt agtgcatctt cattaaaagc agttgatatt cccagttttg aagagagcaa cattgctgtg gaagaagaat ttaaccagcc actttctgta tccaactctt ctctagttgt gagaaaagaa cctgatgtac ctgtgttctt tccaagtggc cagctggcag aaagtgtaag catgtgttta cagactggac caacaggggg tgccagtaac aattctgaaa catcagagga accaaaaatt gagcatgtaa tgcaaccctt gcttcatcaa ccatcagata accagaaaat ttaccaggat ttattgggtc aagtaaacca cctattaaat agttcctcca aggaaactga gcagccgtct accaaagcag taattatcag tcatgaatgc accagaaccc aaaacgttta ccatacaaag aaaaaaacac atcattcaag actggtggac aaagattgtg tccttaatgc aactcttaag caactaagaa gccttggagt aaaaattgat tctcccacta aagtgaagaa aaatgcacat aacgtggatc acgccagtgt gttggcatgc atcagcccag aagcagtgat ctctggatta aactgcatgt catttgctaa tgttggcatg agcggcttaa gccccaatgg tgtggatttg agcatggagg caaatgctat agctctgaaa tatttaaatg aaaatcagct gtcacaactg tctgtcactc gatcgaacca aaataattgt gacccattca gccttctcca tattaataca gacagaagca cagtggggct tagtttaatt tcaccaaaca acatgtcatt tgcaaccaaa aaatatatga agagatatgg actcctacaa agcagtgaca atagtgaaga tgaagaggaa cctcccgaca atgcagatag caagagtgaa tatttattga atcagaacct taggtccata cccgaacagc ttggtggtca gaaagagcct tctaagaatg accatgaaat aattaattgt tctaactgtg aatctgtggg gaccaacgca gatacgccag tattgagaaa tattacaaat gaagttttgc agacaaaagc aaaacagcag ttgactgaaa agccagcttt cttagtaaag aaccttaaac caagtcctgc agtgaacctt cgaaccggga aagcagagtt cactcaacat cctgagaaag aaaatgaagg ggacattaca atttttcctg aaagtttgca accttctgaa acgctaaagc agatgaatag catgaattca gtaggcacct tcttagatgt aaaacgtctc agacagttac caaaattatt ttaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of STIL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for STIL. It may not necessarily be applicable to this product.
NCBI Accession #
BC126223
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UniProt Secondary Accession #
Q5T0C5; Q68CN9[Other Products]
UniProt Related Accession #
Q15468[Other Products]
Molecular Weight
143,042 Da
NCBI Official Full Name
Homo sapiens SCL/TAL1 interrupting locus, mRNA
NCBI Official Synonym Full Names
SCL/TAL1 interrupting locus
NCBI Official Symbol
STIL [Similar Products]
NCBI Official Synonym Symbols
SIL; MCPH7
[Similar Products]
NCBI Protein Information
SCL-interrupting locus protein
UniProt Protein Name
SCL-interrupting locus protein
UniProt Synonym Protein Names
TAL-1-interrupting locus protein
Protein Family
Stilbene synthase
UniProt Gene Name
STIL [Similar Products]
UniProt Synonym Gene Names
SIL [Similar Products]
UniProt Entry Name
STIL_HUMAN
NCBI Summary for STIL
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for STIL
STIL: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. In childhood T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. In cultured lymphocytes from healthy *****s, STIL/TAL1 fusion mRNA may be detected after 7 days of culture. Defects in STIL are the cause of microcephaly primary type 7 (MCPH7). Microcephaly is defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Cell cycle regulation; Oncoprotein
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: centriole; centrosome; cytoplasm
Molecular Function: protein binding
Biological Process: cell proliferation; centrosome duplication; determination of left/right symmetry; embryonic axis specification; floor plate development; forebrain development; heart looping; in utero embryonic development; mitotic spindle organization and biogenesis; multicellular organism growth; negative regulation of apoptosis; neural tube closure; neural tube development; notochord development; regulation of centriole replication; smoothened signaling pathway
Disease: Microcephaly 7, Primary, Autosomal Recessive
Research Articles on STIL
1. The authors suggest that the STIL-coiled-coil region/PLK4 interaction mediates PLK4 activation as well as stabilization of centriolar PLK4 and plays a key role in centriole duplication.
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