Full Product Name
TDP1 Antibody
Product Gene Name
anti-TDP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NUW8
Other Notes
Small volumes of anti-TDP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TDP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001008744.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001008744.1
[Other Products]
UniProt Primary Accession #
Q9NUW8
[Other Products]
UniProt Secondary Accession #
Q2HXX4; Q86TV8; Q96BK7; Q9NZM7; Q9NZM8[Other Products]
UniProt Related Accession #
Q9NUW8[Other Products]
Molecular Weight
41,630 Da
NCBI Official Full Name
tyrosyl-DNA phosphodiesterase 1 isoform a
NCBI Official Synonym Full Names
tyrosyl-DNA phosphodiesterase 1
NCBI Official Symbol
TDP1 [Similar Products]
NCBI Protein Information
tyrosyl-DNA phosphodiesterase 1
UniProt Protein Name
Tyrosyl-DNA phosphodiesterase 1
Protein Family
Tyrosyl-DNA phosphodiesterase
UniProt Gene Name
TDP1 [Similar Products]
UniProt Synonym Gene Names
Tyr-DNA phosphodiesterase 1 [Similar Products]
NCBI Summary for TDP1
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]
UniProt Comments for TDP1
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Research Articles on TDP1
1. Data indicate a molecular basis for DNA 3'-end processing by tyrosyl-DNA phosphodiesterase (Tdp1).
Precautions
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Disclaimer
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