ACCalpha, Polyclonal Antibody

ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-ACCalpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Acetyl/Phospho/Methyl Antibody; Cancer

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)

WB: 1:500-1:2000
IHC: 1:100-1:300
ELISA: 1:10000

Western Blot analysis of 3T3 cells with Phospho-ACCalpha (Ser80) Polyclonal Antibody at dilution of 1:1000

Calculated Molecular Weight: 266kDa
Observed Molecular Weight: 265kDa

acetyl-CoA carboxylase alpha

acetyl-CoA carboxylase 1

Acetyl-CoA carboxylase 1

ACAC; ACC1; ACCA; ACC1  [Similar Products]

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: actin cytoskeleton; cytosol; extracellular exosome; fibrillar center; mitochondrion

Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; identical protein binding; metal ion binding; protein binding

Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; fatty-acyl-CoA biosynthetic process; lipid homeostasis; malonyl-CoA biosynthetic process; multicellular organismal protein metabolic process; positive regulation of cellular metabolic process; protein homotetramerization; regulation of cholesterol biosynthetic process; tissue homeostasis

Disease: Acetyl-coa Carboxylase Deficiency

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