Product Name
Gamma-secretase subunit PEN-2 (Psenen), Recombinant Protein
Full Product Name
Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen), partial
Product Gene Name
Psenen recombinant protein
[Similar Products]
Product Synonym Gene Name
Psenen[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9CQR7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Psenen recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Psenen. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079774.1
[Other Products]
NCBI GenBank Nucleotide #
NM_025498.2
[Other Products]
UniProt Primary Accession #
Q9CQR7
[Other Products]
UniProt Related Accession #
Q9CQR7[Other Products]
Molecular Weight
11,999 Da
NCBI Official Full Name
gamma-secretase subunit PEN-2
NCBI Official Synonym Full Names
presenilin enhancer gamma secretase subunit
NCBI Official Symbol
Psenen [Similar Products]
NCBI Official Synonym Symbols
Pen-2; 1700023M09Rik
[Similar Products]
NCBI Protein Information
gamma-secretase subunit PEN-2
UniProt Protein Name
Gamma-secretase subunit PEN-2
UniProt Synonym Protein Names
Presenilin enhancer protein 2
Protein Family
Gamma-secretase
UniProt Gene Name
Psenen [Similar Products]
UniProt Synonym Gene Names
Pen2 [Similar Products]
UniProt Comments for Psenen
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:24941111).
Research Articles on Psenen
1. Using knockout cell lines in combination with siRNA and immunoprecipitation approaches, our data clearly demonstrated that the Pen-2 and PS1 are sufficient to form a functionally active gamma-secretase that is capable of catalyzing the processing of Notch. This finding strongly suggests that Pen-2 is the most crucial component in gamma-secretase complex in addition to presenilin that functions as the catalytic subunit.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
