Product Name
EVER2 (TMC8), Blocking Peptide
Full Product Name
EVER2 Peptide
Product Synonym Names
EV2; EVER2; EVIN2; Transmembrane channel-like protein 8; Epidermodysplasia verruciformis protein 2; transmembrane channel-like 8
Product Gene Name
TMC8 blocking peptide
[Similar Products]
EVER2 peptide (MBS152438) is used for blocking the activity of EVER2 antibody (MBS150620)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IU68
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
14 amino acids near the amino terminus of human EVER2.
Preparation and Storage
Store EVER2 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of TMC8 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for TMC8 blocking peptide
Blocking (BL)
Application Notes for TMC8 blocking peptide
EVER2 peptide is used for blocking the activity of EVER2 antibody.
NCBI/Uniprot data below describe general gene information for TMC8. It may not necessarily be applicable to this product.
NCBI Accession #
AAM44454
[Other Products]
UniProt Primary Accession #
Q8IU68
[Other Products]
UniProt Secondary Accession #
Q2YDC0; Q8IWU7; Q8N358; Q8NF04[Other Products]
UniProt Related Accession #
Q8IU68[Other Products]
Molecular Weight
56,132 Da
NCBI Official Full Name
large EVER2 protein
NCBI Official Synonym Full Names
transmembrane channel-like 8
NCBI Official Symbol
TMC8 [Similar Products]
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 8; epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2
UniProt Protein Name
Transmembrane channel-like protein 8
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 2
Protein Family
Transmembrane channel-like protein
UniProt Gene Name
TMC8 [Similar Products]
UniProt Synonym Gene Names
EVER2; EVIN2 [Similar Products]
UniProt Entry Name
TMC8_HUMAN
NCBI Summary for TMC8
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
UniProt Comments for TMC8
TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane
Molecular Function: protein binding; receptor binding
Biological Process: negative regulation of protein oligomerization; zinc ion homeostasis; ion transport; regulation of cell growth; negative regulation of protein binding
Disease: Epidermodysplasia Verruciformis
Research Articles on TMC8
1. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB signaling pathways in keratinocytes.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
