TMC6, Polyclonal Antibody

Anti -TMC6, NT (TMC6, EVER1, EVIN1, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000017.10 (76108999..76128488, complement). Location: 17q25.3

Polyclonal

IgG

Rabbit

Human

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-TMC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.

Antibodies; Abs to Transmembrane Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

90,045 Da[Similar Products]

transmembrane channel-like 6

transmembrane channel-like protein 6; protein LAK-4; epidermodysplasia verruciformis 1; expressed in activated T/LAK lymphocytes; epidermodysplasia verruciformis protein 1

Transmembrane channel-like protein 6

EVER1; EVIN1  [Similar Products]

TMC6_HUMAN

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

Function: Probable ion channel

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.

Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. Ref.2 Ref.3

Involvement in disease: Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities: Belongs to the TMC family.

Sequence caution: The sequence AAH35648.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA24179.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB84891.1 differs from that shown. Reason: Erroneous initiation.

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