Product Name
C1 Inhibitor (SERPING1), Antibody
Full Product Name
Sheep anti-C1 Inhibitor - Affinity Pure
Product Gene Name
anti-SERPING1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05155
Species Reactivity
C1 Inhibitor
Specificity
Human C1 Inhibitor
Purity/Purification
> 95% based on SDS-PAGE
Affinity purified using solid phase Human C1 Inhibitor.
Form/Format
Clear, colorless liquid, 0.2 um filtered
Concentration
> 4.5 mg/ml (E 1% at 280 nm = 13.0) (lot specific)
Immunogen
Human C1 Inhibitor
Buffer
10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.05% (w/v) Sodium Azide
Country of Origin
Sheep serum was obtained from healthy animals of UK origin and under the care of a registered veterinarian.
Preparation and Storage
Store at 2-8 degree C
Quality Manufacturing Systems
Manufactured under ISO QSR (Quality System Requirements) guidelines, compliant with ISO 13485:2016.
Other Notes
Small volumes of anti-SERPING1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SERPING1 antibody
Primary Antibodies
Applications Tested/Suitable for anti-SERPING1 antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
NCBI Accession #
CAA30314
[Other Products]
UniProt Primary Accession #
P05155
[Other Products]
UniProt Secondary Accession #
Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; A6NMU0; A8KAI9; B2R6L5; B4E1F0; B4E1H2[Other Products]
UniProt Related Accession #
P05155[Other Products]
Molecular Weight
55,769 Da[Similar Products]
NCBI Official Full Name
C1 inhibitor
NCBI Official Synonym Full Names
serpin family G member 1
NCBI Official Symbol
SERPING1 [Similar Products]
NCBI Official Synonym Symbols
C1IN; C1NH; HAE1; HAE2; C1INH
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NCBI Protein Information
plasma protease C1 inhibitor
UniProt Protein Name
Plasma protease C1 inhibitor
UniProt Synonym Protein Names
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Protein Family
Plasma protease C1 inhibitor
UniProt Gene Name
SERPING1 [Similar Products]
UniProt Synonym Gene Names
C1IN; C1NH; C1 Inh; C1Inh [Similar Products]
NCBI Summary for SERPING1
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPING1
SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with ***** macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: extracellular region; extracellular space
Molecular Function: protein binding; serine-type endopeptidase inhibitor activity
Biological Process: blood circulation; blood coagulation, intrinsic pathway; negative regulation of complement activation, lectin pathway; platelet degranulation
Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
Research Articles on SERPING1
1. This study represents the first Brazilian HAE cohort evaluated for SERPING1 gene mutations and it introduces the possibility to perform genetic analysis in case of need for differential diagnosis.
Precautions
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Disclaimer
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