Phosphoglycerate Kinase 1 (PGK1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of PGK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9372747 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Phosphoglycerate Kinase 1 (PGK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PGK1. The ELISA analytical biochemical technique of the MBS9372747 kit is based on PGK1 antibody-PGK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PGK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PGK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

41,429 Da

phosphoglycerate kinase 1

phosphoglycerate kinase 1

Phosphoglycerate kinase 1

PGKA; PRP 2  [Similar Products]

PGK1_HUMAN

The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

PGK1: an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein).

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; Kinase, other

Chromosomal Location of Human Ortholog: Xq13.3

Cellular Component: cytosol; lipid raft; membrane

Molecular Function: ATP binding; phosphoglycerate kinase activity; protein binding

Biological Process: epithelial cell differentiation; gluconeogenesis; phosphorylation

Disease: Phosphoglycerate Kinase 1 Deficiency

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