Product Name
G protein-activated inward rectifier potassium channel 1 (Kcnj3), Recombinant Protein
Full Product Name
Recombinant Rat G protein-activated inward rectifier potassium channel 1 (Kcnj3)
Product Synonym Names
Recombinant G protein-activated inward rectifier potassium channel 1 (Kcnj3); G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1 KGA KGB1 Potassium channel, inwardly rectifying subfamily J member 3
Product Gene Name
Kcnj3 recombinant protein
[Similar Products]
Product Synonym Gene Name
Kcnj3; Girk1, Kga[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MSALRRKFGD DYQVVTTSSS GSGLQPQGPG QGPQQQLVPK KKRQRFVDKN GRCNVQHGNL GSETSRYLSD LFTTLVDLKW RWNLFIFILT YTVAWLFMAS MWWVIAYTRG DLNKAHVGNY TPCVANVYNF PSAFLFFIET EATIGYGYRY ITDKCPEGII LFLFQSILGS IVDAFLIGCM FIKMSQPKKR AETLMFSEHA VISMRDGKLT LMFRVGNLRN SHMVSAQIRC KLLKSRQTPE GEFLPLDQLE LDVGFSTGAD QLFLVSPLTI CHVIDAKSPF YDLSQRSMQT EQFEVVVILE GIVETTGMTC QARTSYTEDE VLWGHRFFPV ISLEEGFFKV DYSQFHATFE VPTPPYSVKE QEEMLLMSSP LIAPAITNSK ERHNSVECLD GLDDISTKLP SKLQKITGRE DFPKKLLRMS STTSEKAYSL GDLPMKLQRI SSVPGNSEEK LVSKTTKMLS DPMSQSVADL PPKLQKMAGG PTRMEGNLPA KLRKMNSDRF T
Chromosome Location
Chromosome: 3; NC_005102.3 (46103695..46264737). Location: 3q31-q35
3D Structure
ModBase 3D Structure for P63251
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Kcnj3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Kcnj3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_113798.1
[Other Products]
NCBI GenBank Nucleotide #
NM_031610.3
[Other Products]
UniProt Primary Accession #
P63251
[Other Products]
UniProt Secondary Accession #
P35562[Other Products]
UniProt Related Accession #
P63251[Other Products]
Molecular Weight
56,573 Da[Similar Products]
NCBI Official Full Name
G protein-activated inward rectifier potassium channel 1
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 3
NCBI Official Symbol
Kcnj3 [Similar Products]
NCBI Protein Information
G protein-activated inward rectifier potassium channel 1; KGA; KGB1; GIRK1; GIRK-1; inward rectifier K(+) channel Kir3.1; potassium channel subunit Kir3.1 type 3 delta; potassium channel, inwardly rectifying subfamily J member 3; potassium channel inwarding rectifying channel subfamily J member 3
UniProt Protein Name
G protein-activated inward rectifier potassium channel 1
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir3.1; KGA; KGB1; Potassium channel, inwardly rectifying subfamily J member 3
Protein Family
G protein-activated inward rectifier potassium channel
UniProt Gene Name
Kcnj3 [Similar Products]
UniProt Synonym Gene Names
Girk1; Kga; GIRK-1 [Similar Products]
UniProt Entry Name
IRK3_RAT
NCBI Summary for Kcnj3
inwardly-rectifying potassium channel; gated by G-protein beta gamma-subunits [RGD, Feb 2006]
UniProt Comments for Kcnj3
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Subunit structure: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily. [View classification]
Research Articles on Kcnj3
1. The mechanisms of regulation of GIRK by Galpha(i/o) using wild-type Galpha(i3) (Galpha(i3)WT) and Galpha(i3), were investigated.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
