Product Name
G protein-activated inward rectifier potassium channel 1 (Kcnj3), Recombinant Protein
Full Product Name
Recombinant Mouse G protein-activated inward rectifier potassium channel 1 (Kcnj3)
Product Gene Name
Kcnj3 recombinant protein
[Similar Products]
Product Synonym Gene Name
Girk1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-501aa; Full length protein
Sequence
MSALRRKFGD DYQVVTTSSS GSGLQPQGPG QGPQQQLVPK KKRQRFVDKN GRCNVQHGNL GSETSRYLSD LFTTLVDLKW RWNLFIFILT YTVAWLFMAS MWWVIAYTRG DLNKAHVGNY TPCVANVYNF PSAFLFFIET EATIGYGYRY ITDKCPEGII LFLFQSILGS IVDAFLIGCM FIKMSQPKKR AETLMFSEHA VISMRDGKLT LMFRVGNLRN SHMVSAQIRC KLLKSRQTPE GEFLPLDQLE LDVGFSTGAD QLFLVSPLTI CHVIDAKSPF YDLSQRSMQT EQFEVVVILE GIVETTGMTC QARTSYTEDE VLWGHRFFPV ISLEEGFFKV DYSQFHATFE VPTPPYSVKE QEEMLLMSSP LIAPAITNSK ERHNSVECLD GLDDISTKLP SKLQKITGRE DFPKKLLRMS STTSEKAYSL GDLPMKLQRI SSVPGNSEEK LVSKTTKMLS DPMSQSVADL PPKLQKMAGG PTRMEGNLPA KLRKMNSDRF T
3D Structure
ModBase 3D Structure for P63250
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Kcnj3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Kcnj3 recombinant protein
Transmembrane Protein
Application Notes for Kcnj3 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Kcnj3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032452.1
[Other Products]
NCBI GenBank Nucleotide #
NM_008426.2
[Other Products]
UniProt Primary Accession #
P63250
[Other Products]
UniProt Secondary Accession #
P35562[Other Products]
UniProt Related Accession #
P63250[Other Products]
Molecular Weight
56,573 Da
NCBI Official Full Name
G protein-activated inward rectifier potassium channel 1 isoform 1
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 3
NCBI Official Symbol
Kcnj3 [Similar Products]
NCBI Official Synonym Symbols
GIRK1; Kcnf3; GIRK-1; Kir3.1
[Similar Products]
NCBI Protein Information
G protein-activated inward rectifier potassium channel 1
UniProt Protein Name
G protein-activated inward rectifier potassium channel 1
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3
Protein Family
G protein-activated inward rectifier potassium channel
UniProt Gene Name
Kcnj3 [Similar Products]
UniProt Synonym Gene Names
Girk1; GIRK-1 [Similar Products]
UniProt Entry Name
KCNJ3_MOUSE
UniProt Comments for Kcnj3
GIRK1: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Cellular Component: cell surface; external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane; T-tubule
Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; voltage-gated ion channel activity
Biological Process: ion transport; potassium ion import; potassium ion transport; transport
Research Articles on Kcnj3
1. Kir 3.1 channels are important for supraspinal antinociception and presynaptic GABA release inhibition by oxycodone in the femur bone cancer model
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
