Full Product Name
ADA2 Antibody - N-terminal region
Product Gene Name
anti-ADA2 antibody
[Similar Products]
Product Synonym Gene Name
PAN; ADGF; CECR1; IDGFL; SNEDS[Similar Products]
Antibody/Peptide Pairs
ADA2 peptide (MBS3233477) is used for blocking the activity of ADA2 antibody (MBS3208515)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: MQFRFAHPTP RPSEKCSKWI LLEDYRKRVQ NVTEFDDSLL RNFTLVTQHP
3D Structure
ModBase 3D Structure for Q9NZK5
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human CECR1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ADA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADA2 antibody
This is a rabbit polyclonal antibody against CECR1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-ADA2 antibody
Polyclonal; Signal Proteins; Growth Factors & Hormones; Membrane Protein;
Applications Tested/Suitable for anti-ADA2 antibody
Western Blot (WB)
Western Blot (WB) of anti-ADA2 antibody
WB Suggested Anti-CECR1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain
NCBI/Uniprot data below describe general gene information for ADA2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_059120
[Other Products]
NCBI GenBank Nucleotide #
NM_017424
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UniProt Primary Accession #
Q9NZK5
[Other Products]
UniProt Related Accession #
Q9NZK5[Other Products]
NCBI Official Synonym Full Names
adenosine deaminase 2
NCBI Official Symbol
ADA2 [Similar Products]
NCBI Official Synonym Symbols
PAN; ADGF; CECR1; IDGFL; SNEDS
[Similar Products]
NCBI Protein Information
adenosine deaminase 2
UniProt Protein Name
Adenosine deaminase CECR1
UniProt Synonym Protein Names
Cat eye syndrome critical region protein 1
Protein Family
Adenosine deaminase
UniProt Gene Name
CECR1 [Similar Products]
UniProt Synonym Gene Names
ADA2; ADGF; IDGFL [Similar Products]
NCBI Summary for ADA2
This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for ADA2
CECR1: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Belongs to the adenosine and AMP deaminases family. ADGF subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.4.4; Hydrolase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q11.1
Cellular Component: cytosol; extracellular region; extracellular space
Molecular Function: adenosine deaminase activity; adenosine receptor binding; growth factor activity; protein homodimerization activity; proteoglycan binding; zinc ion binding
Biological Process: adenosine catabolic process; cellular protein metabolic process; hypoxanthine salvage; inosine biosynthetic process
Disease: Polyarteritis Nodosa, Childhood-onset; Sneddon Syndrome
Research Articles on ADA2
1. We imposed no clinical selection or criteria before testing but collected uniform clinical data for each patient. Therefore, this series exactly reflects the context of requests for sequencing the ADA2 gene we receive in our laboratory
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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