Pericentrin 1, Polyclonal Antibody

Anti -Pericentrin 1, CT (Pericentrin-1, PCNT1, FLJ12549, Frount, Frount Protein, Kendrin, KEN, Nucleoporin 85, Nucleoporin-85, Nucleoporin 85kDa, NUP85, Nucleoporin Nup75, Nup75, Pericentrin, PCN, PCNT)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 21; NC_000021.8 (47743976..47865682). Location: 21q22.3

Polyclonal

IgG

Goat

Recognizes the C-terminal of human pericentrin 1. Species sequence homology: rat, mouse.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-PCNT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Pericentrin 1 is a 75kD component of the filamentous matrix of the centrosome, expressed in all tissues. When associated with centrosome and Golgi localised protein kinase N-associated protein (CG-NAP), pericentrin 1 anchors the gamma-tubulin ring complex, providing a site for microtubule nucleation and the initial establishment of organized microtubule arrays. It binds calmodulin and is a constituent of nuclear pore proteins (nup) 107-160, a sub-complex of the nuclear pore complex. Pericentrin 1 is thought to play a role in the functioning of the centrosomes, cytoskeleton, and cell-cycle progression.

Antibodies; Abs to Mitosis Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32,000
Western Blot: 1-3ug/ml

378,037 Da[Similar Products]

pericentrin

pericentrin; kendrin; pericentrin B; pericentrin-2; pericentrin-B; pericentrin-380

Pericentrin

KIAA0402; PCNT2  [Similar Products]

PCNT_HUMAN

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]

PCNT: Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2); also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: centriole; microtubule; centrosome; pericentriolar material; intercellular bridge; membrane; cytoplasm; cytosol

Molecular Function: calmodulin binding; protein binding

Biological Process: in utero embryonic development; organelle organization and biogenesis; olfactory bulb development; multicellular organism growth; neuron migration; microtubule cytoskeleton organization and biogenesis; spindle organization and biogenesis; limb morphogenesis; cerebellar cortex morphogenesis; brain morphogenesis; cilium biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of apoptosis

Disease: Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii

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