High Affinity Choline Transporter 1 (SLC5A7), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SLC5A7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9395488 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the High Affinity Choline Transporter 1 (SLC5A7) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC5A7. The ELISA analytical biochemical technique of the MBS9395488 kit is based on SLC5A7 antibody-SLC5A7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC5A7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC5A7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

63,204 Da

solute carrier family 5 member 7

high affinity choline transporter 1

High affinity choline transporter 1

CHT1; CHT  [Similar Products]

This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

SLC5A7: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q12.3

Cellular Component: axon; dendrite; integral to membrane; integral to plasma membrane; perikaryon; plasma membrane; synapse

Molecular Function: choline binding; choline transmembrane transporter activity; choline:sodium symporter activity

Biological Process: acetylcholine biosynthetic process; neuromuscular synaptic transmission; neurotransmitter secretion; synaptic transmission, cholinergic; transmembrane transport

Disease: Myasthenic Syndrome, Congenital, 20, Presynaptic; Neuronopathy, Distal Hereditary Motor, Type Viia

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