Creatine transporter 1/SLC6A8, Polyclonal Antibody

SLC6A8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; CRT; CRTR; CT1; MGC87396; creatine transporter 1; creatine transporter SLC6A8; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 member 8; SLC6A8 antibody; solute carrier family 6 (neurotransmitter transporter; creatine); member 8 antibody; CRT antibody; CRTR antibody; CT1 antibody; MGC87396 antibody; creatine transporter 1 antibody; creatine transporter SLC6A8 antibody; sodium- and chloride-dependent creatine transporter 1 antibody; Creatine transporter 1; Creatine transporter 1 / SLC6A8

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-SLC6A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 70kDa band observed in Mouse Heart, Kidney and Skeletal Muscle lysates (calculated MW of 71. 0kDa according to Mouse NP_598748.1). Recommended concentration: 0.1-0.3ug/ml.

(0.1ug/ml) staining of Mouse Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

58,453 Da

solute carrier family 6 member 8

sodium- and chloride-dependent creatine transporter 1

Sodium- and chloride-dependent creatine transporter 1

CT1; Creatine transporter 1  [Similar Products]

SC6A8_HUMAN

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Motility/polarity/chemotaxis; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: creatine transporter activity; creatine:sodium symporter activity; neurotransmitter:sodium symporter activity

Biological Process: creatine metabolic process; creatine transport; muscle contraction; neurotransmitter transport; sodium ion transport; transport

Disease: Cerebral Creatine Deficiency Syndrome 1

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