KCNK9, Polyclonal Antibody

KT3.2; TASK3; K2p9.1; TASK-3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total KCNK9 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.8 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-KCNK9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:100-1:300

Gel: 8%SDS-PAGE Lysates (from left to right): Human paraneoplastic and normal kidney tissue

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/40.

42kd

potassium channel, two pore domain subfamily K, member 9

potassium channel subfamily K member 9

Potassium channel subfamily K member 9

TASK3; Two pore K(+) channel KT3.2  [Similar Products]

KCNK9_HUMAN

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

KCNK9: pH-dependent, voltage-insensitive, background potassium channel protein. Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: synaptic vesicle; integral to membrane; plasma membrane

Molecular Function: protein homodimerization activity; potassium channel activity; protein heterodimerization activity; voltage-gated ion channel activity

Biological Process: synaptic transmission; potassium ion transport

Disease: Birk-barel Mental Retardation Dysmorphism Syndrome

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