Potassium channel subfamily K member 9, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

This assay has high sensitivity and excellent specificity for detection of Human KCNK9. No significant cross-reactivity or interference between Human KCNK9 and analogues was observed.

Store at 2-8 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of KCNK9 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS281492 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium channel subfamily K member 9 (KCNK9) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNK9. The ELISA analytical biochemical technique of the MBS281492 kit is based on KCNK9 antibody-KCNK9 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNK9 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNK9. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate KCNK9 in samples. An antibody specific for KCNK9 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKCNK9 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KCNK9 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KCNK9 bound in the initial step. The color development is stopped and the intensity of the color is measured.

42,264 Da

potassium two pore domain channel subfamily K member 9

potassium channel subfamily K member 9

Potassium channel subfamily K member 9

TASK3; Two pore K(+) channel KT3.2  [Similar Products]

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

KCNK9: pH-dependent, voltage-insensitive, background potassium channel protein. Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: integral component of plasma membrane; plasma membrane; synaptic vesicle

Molecular Function: potassium channel activity; potassium ion leak channel activity; protein heterodimerization activity; protein homodimerization activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; stabilization of membrane potential

Disease: Birk-barel Mental Retardation Dysmorphism Syndrome

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