Full Product Name
Anti-C1R Antibody
Product Synonym Names
C1R; Complement C1r subcomponent
Product Gene Name
anti-C1R antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P00736
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Immunogen
Complement component 1, r subcomponent
Preparation and Storage
Store at -20 degree C for 24 months. Avoid repeated freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-C1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C1R antibody
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r is a single-chain glycoprotein which can be cleaved into an A chain and a B chain upon activation. This antibody recognizes full-length C1r chain and the cleaved B chain.
Applications Tested/Suitable for anti-C1R antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-C1R antibody
WB: 1:500-1:2000
IHC: 1:50-1:500
Immunohistochemistry (IHC) of anti-C1R antibody
Immunohistochemistry of paraffin-embedded human liver tissue slide using (C1R Antibody) at dilution of 1:200
Testing Data of anti-C1R antibody
human blood tissue were subjected to SDS PAGE followed by western blot with (C1R antibody) at dilution of 1:1000
NCBI/Uniprot data below describe general gene information for C1R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001724.3
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NCBI GenBank Nucleotide #
NM_001733.4
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UniProt Primary Accession #
P00736
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UniProt Related Accession #
P00736[Other Products]
NCBI Official Full Name
complement C1r subcomponent
NCBI Official Synonym Full Names
complement C1r
NCBI Official Symbol
C1R [Similar Products]
NCBI Official Synonym Symbols
EDSPD1
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NCBI Protein Information
complement C1r subcomponent
UniProt Protein Name
Complement C1r subcomponent
UniProt Synonym Protein Names
Complement component 1 subcomponent r
Protein Family
Complement C1r subcomponent
UniProt Gene Name
C1R [Similar Products]
UniProt Entry Name
C1R_HUMAN
NCBI Summary for C1R
This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome. [provided by RefSeq, Dec 2018]
UniProt Comments for C1R
C1R: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.41; Protease
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: extracellular region
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding
Biological Process: innate immune response; immune response; proteolysis; complement activation, classical pathway; complement activation
Disease: Complement Component C1r/c1s Deficiency
Research Articles on C1R
1. The serine protease domains of C1r and C1s are at the periphery of the C1r2s2 tetramer both when alone or within the nonactivated C1 complex. The C1 complex adopts a conformation incompatible with intramolecular activation of C1. Instead, intermolecular proteolytic activation between neighboring C1 complexes bound to a complement-activating surface occurs. Many structurally unrelated molecular patterns can activate C1.
Precautions
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