SLC6A8, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Protein A purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-SLC6A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against SLC6A8. It was validated on Western Blot and immunohistochemistry

Target Description: SLC6A8 is required for the uptake of creatine in muscles and brain.

Polyclonal; Membrane Protein; Drugs and Drug Metabolism; Tissue Specific & Cell Marker; Immunohistochemistry;

Immunohistochemistry (IHC), Western Blot (WB)

Rabbit Anti-SLC6A8 Antibody
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

Host: Rabbit
Target Name: SLC6A8
Sample Tissue: Human MDA-MB-435s, Human THP-1
Antibody Dilution: 1.0ug/ml

WB Suggested Anti-SLC6A8 Antibody Titration: 2.5ug/ml
Positive Control: MDA-MB-435S cell lysateSLC6A8 is strongly supported by BioGPS gene expression data to be expressed in Human MDA-MB435 cells

70kDa

solute carrier family 6 member 8

sodium- and chloride-dependent creatine transporter 1

Sodium- and chloride-dependent creatine transporter 1

CT1  [Similar Products]

SC6A8_HUMAN

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: creatine transporter activity; neurotransmitter:sodium symporter activity; creatine:sodium symporter activity

Biological Process: muscle contraction; neurotransmitter transport; transport; sodium ion transport; creatine metabolic process; creatine transport

Disease: Cerebral Creatine Deficiency Syndrome 1

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