Full Product Name
IP3KC Antibody
Product Synonym Names
Inositol-trisphosphate 3-kinase C; EC 2.7.1.127; Inositol 1; 4; 5-trisphosphate 3-kinase C
Product Gene Name
anti-IP3KC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96DU7
Specificity
The antibody detects endogenous levels of total IP3KC protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from internal of human IP3KC.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-IP3KC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IP3KC antibody
Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate By similarity.Dewaste V., Biochem. J. 352:343-351(2000).Dewaste V., Biochem. J. 374:41-49(2003).Structural genomics consortium (SGC), Submitted (OCT-2005) to the PDB data bank.
Product Categories/Family for anti-IP3KC antibody
Total protein Ab
Applications Tested/Suitable for anti-IP3KC antibody
Western Blot (WB)
Application Notes for anti-IP3KC antibody
Western blotting: 1:500~1:3000
Western Blot (WB) of anti-IP3KC antibody
Western blot analysis of extracts from HT-29 cells, using IP3KC antibody.
NCBI/Uniprot data below describe general gene information for IP3KC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079470.1
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NCBI GenBank Nucleotide #
NM_025194.2
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UniProt Primary Accession #
Q96DU7
[Other Products]
UniProt Secondary Accession #
Q9UE25; Q9Y475[Other Products]
UniProt Related Accession #
Q96DU7[Other Products]
Molecular Weight
75,207 Da
NCBI Official Full Name
inositol-trisphosphate 3-kinase C
NCBI Official Synonym Full Names
inositol-trisphosphate 3-kinase C
NCBI Official Symbol
ITPKC [Similar Products]
NCBI Official Synonym Symbols
IP3KC; IP3-3KC
[Similar Products]
NCBI Protein Information
inositol-trisphosphate 3-kinase C
UniProt Protein Name
Inositol-trisphosphate 3-kinase C
UniProt Synonym Protein Names
Inositol 1,4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; InsP 3-kinase C
UniProt Gene Name
ITPKC [Similar Products]
UniProt Synonym Gene Names
IP3KC; IP3 3-kinase C; IP3K C; InsP 3-kinase C [Similar Products]
UniProt Entry Name
IP3KC_HUMAN
NCBI Summary for IP3KC
This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
UniProt Comments for IP3KC
ITPKC: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Defects in ITPKC are a cause of Kawasaki disease (KWD); also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries. Belongs to the inositol phosphokinase (IPK) family.
Protein type: Kinase, lipid; EC 2.7.1.127; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: nucleus; cytosol
Molecular Function: calmodulin binding; inositol trisphosphate 3-kinase activity; ATP binding
Biological Process: inositol phosphate metabolic process; phosphorylation
Disease: Kawasaki Disease
Research Articles on IP3KC
1. SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease
Precautions
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Disclaimer
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