Product Name
Doublecortin domain-containing protein 2 (DCDC2), Recombinant Protein
Full Product Name
Recombinant Human Doublecortin domain-containing protein 2 (DCDC2)
Product Gene Name
DCDC2 recombinant protein
[Similar Products]
Product Synonym Gene Name
DCDC2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-476aa, full length protein
Sequence
MSGSSARSSH LSQPVVKSVL VYRNGDPFYA GRRVVIHEKK VSSFEVFLKE VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI QSGGNYVAGG QEAFKKLNYL DIGEIKKRPM EVVNTEVKPV IHSRINVSAR FRKPLQEPCT IFLIANGDLI NPASRLLIPR KTLNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE LENGQFYVAV GRDKFKKLPY SELLFDKSTM RRPFGQKASS LPPIVGSRKS KGSGNDRHSK STVGSSDNSS PQPLKRKGKK EDVNSEKLTK LKQNVKLKNS QETIPNSDEG IFKAGAERSE TRGAAEVQED EDTQVEVPVD QRPAEIVDEE EDGEKANKDA EQKEDFSGMN GDLEEEGGRE ATDAPEQVEE ILDHSEQQAR PARVNGGTDE ENGEELQQVN NELQLVLDKE RKSQGAGSGQ DEADVDPQRP PRPEVKITSP EENENNQQNK DYAAVA
3D Structure
ModBase 3D Structure for Q9UHG0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DCDC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DCDC2 recombinant protein
This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Mutations in this gene have been associated with Reading Disability (RD), also referred to as developmental dyslexia.
NCBI/Uniprot data below describe general gene information for DCDC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001182539.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001195610.1
[Other Products]
UniProt Primary Accession #
Q9UHG0
[Other Products]
UniProt Secondary Accession #
Q5VTR8; Q5VTR9; Q86W35; Q9UFD1; Q9UHG1; Q9ULR6[Other Products]
UniProt Related Accession #
Q9UHG0[Other Products]
Molecular Weight
25,582 Da
NCBI Official Full Name
doublecortin domain-containing protein 2
NCBI Official Synonym Full Names
doublecortin domain containing 2
NCBI Official Symbol
DCDC2 [Similar Products]
NCBI Official Synonym Symbols
NSC; RU2; RU2S; DCDC2A; DFNB66; NPHP19
[Similar Products]
NCBI Protein Information
doublecortin domain-containing protein 2
UniProt Protein Name
Doublecortin domain-containing protein 2
UniProt Synonym Protein Names
Protein RU2S
Protein Family
Doublecortin domain-containing protein
UniProt Gene Name
DCDC2 [Similar Products]
UniProt Synonym Gene Names
KIAA1154; RU2 [Similar Products]
NCBI Summary for DCDC2
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for DCDC2
Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779).
Research Articles on DCDC2
1. Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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