Product Name
SPATA7, Polyclonal Antibody
Full Product Name
SPATA7 Polyclonal Antibody
Product Synonym Names
HEL-S-296; HSD-3.1; HSD3; LCA3
Product Gene Name
anti-SPATA7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MNIKQASNCV TYDAKEKIAP LPLEGHDSTW DEIKDDALQH SSPRAMCQYS LKPPSTRKIY SDEEELLYLS FIEDVTDEIL KLGLFSNRFL ERLFERHIKQ NKHLEEEKMR HLLHVLKVDL GCTSEENSVK QNDVDMLNVF DFEKAGNSEP NELKNESEVT IQQERQQYQK ALDMLLSAPK DENEIFPSPT EFFMPIYKSK HSEGVIIQQV NDETNLETST LDENHPSISD SLTDRETSVN VIEGDSDPEK VEISN
3D Structure
ModBase 3D Structure for Q9P0W8
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human SPATA7
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Cytoplasm, cilium axoneme, cilium basal body, cytoskeleton
Positive Samples
U-87MG, Mouse testis, Mouse brain, Rat brain
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-SPATA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SPATA7 antibody
This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-SPATA7 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-SPATA7 antibody
Western Blot (WB)
Application Notes for anti-SPATA7 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-SPATA7 antibody
Western blot analysis of extracts of various cell lines, using SPATA7 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
NCBI/Uniprot data below describe general gene information for SPATA7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035518.1
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NCBI GenBank Nucleotide #
NM_001040428.3
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UniProt Primary Accession #
Q9P0W8
[Other Products]
UniProt Secondary Accession #
Q5BKY5; Q8WX30; Q96HF3; Q9H0X0; Q9P0W7[Other Products]
UniProt Related Accession #
Q9P0W8[Other Products]
Molecular Weight
Calculated: 51kDa; 64kDa; 67kDa
Observed: 75kDa
NCBI Official Full Name
spermatogenesis-associated protein 7 isoform 2
NCBI Official Synonym Full Names
spermatogenesis associated 7
NCBI Official Symbol
SPATA7 [Similar Products]
NCBI Official Synonym Symbols
HSD3; LCA3; HSD-3.1; HEL-S-296
[Similar Products]
NCBI Protein Information
spermatogenesis-associated protein 7
UniProt Protein Name
Spermatogenesis-associated protein 7
UniProt Synonym Protein Names
HSD-3.1; Spermatogenesis-associated protein HSD3
Protein Family
Spermatogenesis-associated protein
UniProt Gene Name
SPATA7 [Similar Products]
UniProt Synonym Gene Names
HSD3 [Similar Products]
NCBI Summary for SPATA7
This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
UniProt Comments for SPATA7
Involved in photoreceptor cells maintenance (). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments ().
Research Articles on SPATA7
1. The disease resulting from SPATA7 mutations in this patient initially presented as a cone-rod dystrophy (CRD), but changed over time into a phenotype more reminiscent of late-stage retinitis pigmentosa (RP).
Precautions
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Disclaimer
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