Full Product Name
TIAM2 Antibody, FITC Conjugated
Product Synonym Names
T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; SIF and TIAM1-like exchange factor; TIAM2; KIAA2016; STEF
Product Gene Name
anti-TIAM2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IVF5
Purity/Purification
>95%
Protein G Purified
Immunogen
Recombinant Human T-lymphoma invasion and metastasis-inducing protein 2 protein (1500-1627AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TIAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TIAM2 antibody
Signal Transduction
Applications Tested/Suitable for anti-TIAM2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for TIAM2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001010927.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001010927.2
[Other Products]
UniProt Primary Accession #
Q8IVF5
[Other Products]
UniProt Secondary Accession #
Q6NXN9; Q6ZUP9; Q9UFG6; Q9UKV9; Q9UKW0; B2RP56; C9JZV2[Other Products]
UniProt Related Accession #
Q8IVF5[Other Products]
Molecular Weight
193,398 Da
NCBI Official Full Name
T-lymphoma invasion and metastasis-inducing protein 2 isoform b
NCBI Official Synonym Full Names
T cell lymphoma invasion and metastasis 2
NCBI Official Symbol
TIAM2 [Similar Products]
NCBI Official Synonym Symbols
STEF; TIAM-2
[Similar Products]
NCBI Protein Information
T-lymphoma invasion and metastasis-inducing protein 2
UniProt Protein Name
T-lymphoma invasion and metastasis-inducing protein 2
UniProt Synonym Protein Names
SIF and TIAM1-like exchange factor
Protein Family
T-lymphoma invasion and metastasis-inducing protein
UniProt Gene Name
TIAM2 [Similar Products]
UniProt Synonym Gene Names
KIAA2016; STEF; TIAM-2 [Similar Products]
NCBI Summary for TIAM2
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for TIAM2
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (). Activates specifically RAC1, but not CDC42 and RHOA.
Research Articles on TIAM2
1. The authors show that the Rac1 selective guanine nucleotide exchange factor Sif and TIAM1-like Exchange Factor STEF, also known as TIAM2, localises to the nuclear envelope, co-localises with key perinuclear proteins and regulates the activity of perinuclear Rac1.
Precautions
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Disclaimer
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