Alpha Fodrin, Polyclonal Antibody

NEAS; SPTA2; Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of Alpha Fodrin protein.

The antibody was purified by affinity chromatography.

Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% Sodium Azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-SPTAN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to Alpha Fodrin

Western Blot (WB), Immunoprecipitation (IP)

Western Blot: (1/500 - 1/1000); Immunoprecipitation: (1/10 - 1/100)

Western blot analysis of Alpha Fodrin expression in A549 (A), Hela (B) whole cell lysates.

282,282 Da

spectrin alpha, non-erythrocytic 1

spectrin alpha chain, non-erythrocytic 1

Spectrin alpha chain, non-erythrocytic 1

NEAS; SPTA2  [Similar Products]

SPTN1_HUMAN

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

SPTAN1: a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytosol; fascia adherens; intracellular membrane-bound organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; protein complex; spectrin; Z disc

Molecular Function: actin binding; calcium ion binding; calmodulin binding; protein binding; protein complex binding; protein heterodimerization activity; protein N-terminus binding; structural constituent of cytoskeleton; syntaxin binding

Biological Process: actin cytoskeleton reorganization; actin filament capping; activation of MAPKK activity; apoptosis; axon guidance; cell structure disassembly during apoptosis; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; ER to Golgi vesicle-mediated transport; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; post-translational protein modification; programmed cell death; protein amino acid N-linked glycosylation via asparagine; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Epileptic Encephalopathy, Early Infantile, 5

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.