Map2k2, Blocking Peptide

Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2; Map2k2; Mek2; Mkk2; Prkmk2

For Research Use Only. Not for use in diagnostic procedures.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of Map2k2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.

44,402 Da

mitogen-activated protein kinase kinase 2

dual specificity mitogen-activated protein kinase kinase 2

Dual specificity mitogen-activated protein kinase kinase 2

Mek2; Mkk2; Prkmk2; MAP kinase kinase 2; MAPKK 2; MEK 2  [Similar Products]

MP2K2_MOUSE

MEK2: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; STE group; STE7 family

Cellular Component: cell cortex; cytoplasm; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; intercellular junction; internal side of plasma membrane; late endosome; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal membrane

Molecular Function: ATP binding; MAP kinase kinase activity; PDZ domain binding; protein binding; protein complex scaffold; protein serine/threonine kinase activator activity; protein serine/threonine/tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; heart development; MAPKKK cascade; positive regulation of axonogenesis; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of axon regeneration; regulation of protein amino acid phosphorylation; regulation of stress-activated MAPK cascade; thymus development; thyroid gland development

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