ADCY5, Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab); Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; ADCY5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Ig

Rabbit

This ADCY5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 604-639 amino acids from the Central region of human ADCY5.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Cancer; Metabolism; Signal Transduction

Western Blot (WB)

WB ~~ 1:1000-1:2000

All lanes : Anti-ADCY5 Antibody (Center) at 1:1000-1:2000 dilution
Lane 1: Hela whole cell lysate
Lane 2: SH-SY5Y whole cell lysate

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 139 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

138908

adenylate cyclase 5

adenylate cyclase type 5

Adenylate cyclase type 5

AC5  [Similar Products]

ADCY5_HUMAN

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Adenylyl cyclase; Membrane protein, integral; Transporter, aquaporin family; EC 4.6.1.1; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Lyase

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: plasma membrane; integral to membrane; intracellular; cytosol

Molecular Function: protein heterodimerization activity; metal ion binding; ATP binding; adenylate cyclase binding; adenylate cyclase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; locomotory behavior; signal transduction; G-protein signaling, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; synaptic transmission; elevation of cytosolic calcium ion concentration; cAMP-mediated signaling; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; neuromuscular process controlling balance; transmembrane transport; adenosine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway

Disease: Dyskinesia, Familial, With Facial Myokymia

Ota T.,et al.Nat. Genet. 36:40-45(2004). Muzny D.M.,et al.Nature 440:1194-1198(2006). Ludwig M.G.,et al.J. Recept. Signal Transduct. 22:79-110(2002). Raimundo S.,et al.Clin. Chim. Acta 285:155-161(1999). Ding Q.,et al.Mol. Pharmacol. 66:921-928(2004).

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