SH3 and PX domains 2B, ELISA Kit

Human SH3 and PX domain-containing protein 2B (SH3PXD2B) ELISA kit; FAD49; FLJ20831; HOFI; KIAA1295; adaptor protein HOFI; SH3 and PX domains 2B

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SH3PXD2B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334398 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the SH3 and PX domains 2B (SH3PXD2B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SH3PXD2B. The ELISA analytical biochemical technique of the MBS9334398 kit is based on SH3PXD2B antibody-SH3PXD2B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SH3PXD2B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SH3PXD2B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

101,579 Da

SH3 and PX domains 2B

SH3 and PX domain-containing protein 2B; adapter protein HOFI; adaptor protein HOFI; factor for adipocyte differentiation 49; tyrosine kinase substrate with four SH3 domains

SH3 and PX domain-containing protein 2B

FAD49; KIAA1295; TKS4  [Similar Products]

SPD2B_HUMAN

This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome. [provided by RefSeq, Sep 2010]

SH3PXD2B: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS). It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers. Belongs to the SH3PXD2 family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cell projection; cytoplasm; podosome; cell junction

Molecular Function: protein binding; phosphatidylinositol-5-phosphate binding; SH2 domain binding; phosphatidylinositol 3-phosphate binding

Biological Process: extracellular matrix disassembly; eye development; heart development; superoxide metabolic process; positive regulation of fat cell differentiation; cell differentiation; skeletal development

Disease: Frank-ter Haar Syndrome

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