Product Name
NBN, Blocking Peptide
Full Product Name
NBN Peptide - middle region
Product Gene Name
NBN blocking peptide
[Similar Products]
NBN peptide (MBS3224979) is used for blocking the activity of NBN antibody (MBS3200230)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: TGLKTTTPGP SLSQGVSVDE KLMPSAPVNT TTYVADTESE QADTWDLSER
3D Structure
ModBase 3D Structure for O60934
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of NBN blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NBN blocking peptide
This is a synthetic peptide designed for use in combination with anti-NBN Antibody, made
Target Description: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Product Categories/Family for NBN blocking peptide
Peptide
Applications Tested/Suitable for NBN blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for NBN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002476.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002485.4
[Other Products]
UniProt Primary Accession #
O60934
[Other Products]
UniProt Related Accession #
O60934[Other Products]
NCBI Official Full Name
nibrin isoform 1
NCBI Official Synonym Full Names
nibrin
NCBI Official Symbol
NBN [Similar Products]
NCBI Official Synonym Symbols
ATV; NBS; P95; NBS1; AT-V1; AT-V2
[Similar Products]
NCBI Protein Information
nibrin
UniProt Protein Name
Nibrin
UniProt Synonym Protein Names
Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1
UniProt Gene Name
NBN [Similar Products]
UniProt Synonym Gene Names
NBS; NBS1; P95 [Similar Products]
UniProt Entry Name
NBN_HUMAN
NCBI Summary for NBN
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
UniProt Comments for NBN
NBS1: a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome.
Protein type: Cell cycle regulation; DNA repair, damage
Chromosomal Location of Human Ortholog: 8q21
Cellular Component: nucleoplasm; PML body; Mre11 complex; nuclear chromosome, telomeric region; nucleolus; replication fork; nucleus; nuclear inclusion body
Molecular Function: ATP-dependent DNA helicase activity; protein binding; damaged DNA binding; protein N-terminus binding; transcription factor binding
Biological Process: DNA damage response, signal transduction by p53 class mediator; mitotic cell cycle checkpoint; positive regulation of kinase activity; isotype switching; DNA repair; positive regulation of protein amino acid autophosphorylation; DNA duplex unwinding; double-strand break repair via homologous recombination; regulation of DNA replication initiation; cell proliferation; meiotic cell cycle; double-strand break repair; mitotic cell cycle G2/M transition DNA damage checkpoint; DNA damage checkpoint; blastocyst growth; cell cycle arrest; neuromuscular process controlling balance; telomere maintenance
Disease: Leukemia, Acute Lymphoblastic; Nijmegen Breakage Syndrome; Aplastic Anemia
Research Articles on NBN
1. it is discovered that MRE11 and NBS1 should start diffusion from significantly different starting positions which suggests that diffusion might not be the only transport mechanism of repair protein recruitment to the DNA break.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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