Product Name
C-C motif chemokine 13 (CCL13), Recombinant Protein
Full Product Name
Recombinant Human C-C motif chemokine 13 protein (CCL13)
Product Synonym Names
CCL13; MCP4; NCC1; SCYA13
Product Gene Name
CCL13 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99616
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of CCL13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CCL13. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005399.1
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NCBI GenBank Nucleotide #
NM_005408.2
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UniProt Primary Accession #
Q99616
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UniProt Secondary Accession #
O95689; Q6ICQ6[Other Products]
UniProt Related Accession #
Q99616[Other Products]
NCBI Official Full Name
C-C motif chemokine 13
NCBI Official Synonym Full Names
C-C motif chemokine ligand 13
NCBI Official Symbol
CCL13 [Similar Products]
NCBI Official Synonym Symbols
NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13
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NCBI Protein Information
C-C motif chemokine 13
UniProt Protein Name
C-C motif chemokine 13
UniProt Synonym Protein Names
CK-beta-10; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL13 [Similar Products]
UniProt Synonym Gene Names
MCP4; NCC1; SCYA13; MCP-4 [Similar Products]
NCBI Summary for CCL13
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
UniProt Comments for CCL13
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular region; extracellular space
Molecular Function: CCR chemokine receptor binding; chemokine activity; receptor binding
Biological Process: cell-cell signaling; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; killing of cells of another organism; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity; regulation of cell shape; signal transduction
Research Articles on CCL13
1. The reduction of circulating levels of MCP-4, eotaxin-3, and MIP-1beta could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.
Precautions
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Disclaimer
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