Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 (GABRA6), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GABRA6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9363022 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 (GABRA6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GABRA6. The ELISA analytical biochemical technique of the MBS9363022 kit is based on GABRA6 antibody-GABRA6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GABRA6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GABRA6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

51,024 Da

gamma-aminobutyric acid type A receptor alpha6 subunit

gamma-aminobutyric acid receptor subunit alpha-6

Gamma-aminobutyric acid receptor subunit alpha-6

GBRA6_HUMAN

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]

GABRA6: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.

Protein type: Transporter; Transporter, ion channel; Membrane protein, integral; Channel, chloride; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cell junction; integral to plasma membrane; plasma membrane; postsynaptic membrane

Molecular Function: benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity

Biological Process: gamma-aminobutyric acid signaling pathway; signal transduction; synaptic transmission; transmembrane transport; transport

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