Product Name
5-Alpha Reductase / SRD5A1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human 5-Alpha Reductase / SRD5A1
Product Synonym Names
Anti-5-Alpha Reductase / SRD5A1 Antibody (N-Terminus) IHC-plus; SRD5A1; 5-alpha reductase; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1; Human 5-Alpha Reductase; SRD5A1
Product Gene Name
anti-SRD5A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P18405
Species Reactivity
Gibbon, Human
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity)
Specificity
Human SRD5A1.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Immunogen Description
Synthetic peptide ATATGVAEERLLC from the N-terminus of human SRD5A1 (NP_001038.1). Percent identity by BLAST analysis: Human, Gibbon (100%); Gorilla, Marmoset (92%); Ajellomyces (83%).
Immunogen Type
Synthetic peptide
Immunogen
5-Alpha Reductase / SRD5A1 antibody was raised against synthetic peptide ATATGVAEERLLC from the N-terminus of human SRD5A1 (NP_001038.1). Percent identity by BLAST analysis: Human, Gibbon (100%); Gorilla, Marmoset (92%); Ajellomyces (83%).
Antigen Modification
N-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-SRD5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SRD5A1 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-SRD5A1 antibody
ELISA (1:64000), IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Immunohistochemistry (IHC) of anti-SRD5A1 antibody
Anti-SRD5A1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
NCBI/Uniprot data below describe general gene information for SRD5A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001038.1
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NCBI GenBank Nucleotide #
NM_001047.2
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UniProt Primary Accession #
P18405
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UniProt Secondary Accession #
Q9UHY4; Q9UP36; Q9UP37; B2R7Q1[Other Products]
UniProt Related Accession #
P18405[Other Products]
Molecular Weight
29,459 Da
NCBI Official Full Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
NCBI Official Synonym Full Names
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
NCBI Official Symbol
SRD5A1 [Similar Products]
NCBI Official Synonym Symbols
S5AR 1
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NCBI Protein Information
3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; 5-alpha reductase; steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1
UniProt Protein Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt Synonym Protein Names
SR type 1; Steroid 5-alpha-reductase 1; S5AR 1
Protein Family
3-oxo-5-alpha-steroid 4-dehydrogenase
UniProt Gene Name
SRD5A1 [Similar Products]
UniProt Synonym Gene Names
S5AR 1 [Similar Products]
UniProt Entry Name
S5A1_HUMAN
NCBI Summary for SRD5A1
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
UniProt Comments for SRD5A1
SRD5A1: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Belongs to the steroid 5-alpha reductase family.
Protein type: Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; EC 1.3.1.22
Chromosomal Location of Human Ortholog: 5p15
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: electron carrier activity; cholestenone 5-alpha-reductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity
Biological Process: steroid metabolic process; sex determination; androgen biosynthetic process; cell differentiation; sex differentiation
Research Articles on SRD5A1
1. Increased 5alphaR activity and glucocorticoid secretion rate over time are linked with the development of metabolic disease, and may represent targets for therapeutic intervention.
Precautions
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Disclaimer
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