Product Name
Calcitonin Receptor (CALCR), Monoclonal Antibody
Full Product Name
Calcitonin Receptor (Calcitonin Receptor Precursor, CALCR, CRT, CT R, CTR, CT-R, CTR1)
Product Synonym Names
Anti -Calcitonin Receptor (Calcitonin Receptor Precursor, CALCR, CRT, CT R, CTR, CT-R, CTR1)
Product Gene Name
anti-CALCR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (93053799..93204042, complement). Location: 7q21.3
3D Structure
ModBase 3D Structure for P30988
Specificity
Recognizes human CALCITONIN Receptor
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide derived from sequence of human calcitonin receptor.
Hybridoma
Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CALCR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CALCR antibody
Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-CALCR antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-CALCR antibody
Suitable for use in ELISA and Immunohistochemistry (paraffin).
Dilution: ELISA: 1:10,000-1:5,000
Immunohistochemistry (paraffin): 1:50-1:500
NCBI/Uniprot data below describe general gene information for CALCR. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P30988
[Other Products]
UniProt Secondary Accession #
O14585; Q13941; Q6DJU8; Q6T712[Other Products]
UniProt Related Accession #
P30988; Q5ZGL8; Q659U6[Other Products]
Molecular Weight
57,303 Da[Similar Products]
NCBI Official Full Name
calcitonin receptor
NCBI Official Synonym Full Names
calcitonin receptor
NCBI Official Symbol
CALCR [Similar Products]
NCBI Official Synonym Symbols
CRT; CTR; CT-R; CTR1
[Similar Products]
NCBI Protein Information
calcitonin receptor; OTTHUMP00000162535; OTTHUMP00000208683; OTTHUMP00000208686
UniProt Protein Name
Calcitonin receptor
Protein Family
Calcitonin receptor
UniProt Gene Name
CALCR [Similar Products]
UniProt Entry Name
CALCR_HUMAN
NCBI Summary for CALCR
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq]
UniProt Comments for CALCR
CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; calcitonin binding; receptor activity; protein transporter activity; calcitonin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; protein transport; phospholipase C activation; receptor internalization; response to glucocorticoid stimulus; adenylate cyclase activation; positive regulation of cAMP biosynthetic process; positive regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase activating pathway
Disease: Osteoporosis
Research Articles on CALCR
1. Allele C in CALCR gene was associated with reduced bone mass in cystic fibrosis children.
Precautions
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Disclaimer
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