SLC34A2, Polyclonal Antibody

NPTIIb; NAPI-3B; NAPI-IIb

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total SLC34A2 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.4 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-SLC34A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:100-1:300

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/70.

Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using at dilution 1/70.

75,657 Da

solute carrier family 34 (type II sodium/phosphate cotransporter), member 2

sodium-dependent phosphate transport protein 2B

Sodium-dependent phosphate transport protein 2B

Sodium-phosphate transport protein 2B; Na(+)/Pi cotransporter 2B; NaPi-2b  [Similar Products]

NPT2B_HUMAN

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

SLC34A2: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM). Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. A chromosomal aberration involving SLC34A2 is found in a non-small cell lung cancer cell line. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: integral to plasma membrane; microvillus membrane; brush border membrane; apical plasma membrane; plasma membrane; integral to membrane; vesicle

Molecular Function: protein domain specific binding; sodium ion binding; phosphate binding; sodium:phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity

Biological Process: cellular phosphate ion homeostasis; phosphate transport; in utero embryonic development; response to estrogen stimulus; ion transport; transmembrane transport; response to fructose stimulus; response to estradiol stimulus; aging

Disease: Pulmonary Alveolar Microlithiasis; Testicular Microlithiasis

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