AGTR1, Polyclonal Antibody

Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1; AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This AGTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human AGTR1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-AGTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Angiotensin II is a potent vasopressor hormone and a
primary regulator of aldosterone secretion. It is an important
effector controlling blood pressure and volume in the
cardiovascular system. It acts through at least two types of
receptors. This gene encodes the type 1 receptor which is thought
to mediate the major cardiovascular effects of angiotensin II. This
gene may play a role in the generation of reperfusion arrhythmias
following restoration of blood flow to ischemic or infarcted
myocardium. It was previously thought that a related gene, denoted
as AGTR1B, existed; however, it is now believed that there is only
one type 1 receptor gene in humans. At least five transcript
variants have been described for this gene. Additional variants
have been described but their full-length nature has not been
determined. The entire coding sequence is contained in the terminal
exon and is present in all transcript variants. [provided by
RefSeq].

Cancer; Cardiovascular; Metabolism; Signal Transduction; Phospho Antibodies

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

AGTR1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the AGTR1 antibody detected the AGTR1 protein (arrow).

AGTR1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AGTR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Confocal immunofluorescent analysis of AGTR1 Antibody (Center) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

AGTR1 Antibody (Center) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

41061

angiotensin II receptor, type 1

type-1 angiotensin II receptor

Type-1 angiotensin II receptor

AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1  [Similar Products]

AGTR1_HUMAN

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; angiotensin type II receptor activity; protein heterodimerization activity; angiotensin type I receptor activity; bradykinin receptor binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vasodilation; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; calcium-mediated signaling; regulation of systemic arterial blood pressure by renin-angiotensin; Rho protein signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; renin-angiotensin regulation of blood vessel size; regulation of vasoconstriction; regulation of inflammatory response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of cell growth; kidney development; positive regulation of phospholipase A2 activity; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity

Disease: Renal Tubular Dysgenesis; Hypertension, Essential

Xu, M., et al. Atherosclerosis 213(1):191-199(2010)
Niu, W., et al. Hypertens. Res. 33(11):1137-1143(2010)
Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Schuur, M., et al. J. Neurol. Neurosurg. Psychiatr. (2010) In press :

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