ASPSCR1, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-ASPSCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Polyclonal; Cancer; Transcription Regulation; Membrane Protein;

Western Blot (WB)

Host: Rabbit
Target Name: ASPSCR1
Sample Tissue: Human Hela Whole Cell lysates
Antibody Dilution: 1ug/ml

71 kDa

ASPSCR1 tether for SLC2A4, UBX domain containing

tether containing UBX domain for GLUT4

Tether containing UBX domain for GLUT4

ASPL; RCC17; TUG; UBXD9; UBXN9  [Similar Products]

ASPC1_HUMAN

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]

ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; Vesicle; Oncoprotein

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; internal side of plasma membrane; ER-Golgi intermediate compartment membrane; extrinsic to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; endomembrane system; vesicle membrane; cytosol

Molecular Function: protein binding

Biological Process: intracellular protein transport; regulation of glucose import; glucose homeostasis

Disease: Alveolar Soft Part Sarcoma

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