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Cofilin 2, Polyclonal Antibody

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产品名称: Cofilin 2, Polyclonal Antibody
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简单介绍

Cofilin 2, Polyclonal Antibody


Cofilin 2, Polyclonal Antibody  的详细介绍
Product Name

Cofilin 2 (CFL2), Polyclonal Antibody

Full Product Name

Cofilin 2, phosphorylated (Ser3)

Product Synonym Names
Anti -Cofilin 2, phosphorylated (Ser3)
Product Gene Name

anti-CFL2 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 14; NC_000014.8 (35179588..35184029, complement). Location: 14q12
3D Structure
ModBase 3D Structure for Q549N0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Chicken, Human, Mouse
Specificity
Recognizes human phospho-Cofilin 2, Mr 21kD.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, before the addition of glycerol to 30%.
Immunogen
Synthetic peptide corresponding to aa1-10 (MA[pS]GVTVNDE-C) of human phospho-Cofilin 2, with a C-terminal cysteine added for conjugation purposes, conjugated to KLH. Species Sequence Homology: chicken, mouse; 100%.
Species Sequence Homology
Chicken, mouse; 100%.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CFL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-CFL2 antibody
Cofilin is a small actin-binding protein that plays a pivotal role in cytokinesis, endocytosis, embryonic development, stress response and tissue regeneration.
Product Categories/Family for anti-CFL2 antibody
Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-CFL2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CFL2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-4ug/ml detects phospho-Cofilin 2 in RIPA lysates from L6 cells, treated with LIM Kinase 1, active, Recombinant for 30 minutes. Cofilin 2 is phosphorylated at Ser3 by LIM Kinase. 500ug L6 lysate was incubated with or without 100mU LIM Kinase at 30 degree C for 30 minutes. Phosphorylation was terminated by boiling in reducing sample buffer. Aliquots (10ug) were resolved by electrophoresis and subjected to Western Blot, using 1ug/ml C7506-51. Proteins were visualized using an IgG (HRP) goat anti-rabbit and a chemiluminescence detection system.
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NCBI/Uniprot data below describe general gene information for CFL2. It may not necessarily be applicable to this product.
NCBI GI #
33946278
NCBI GeneID
1073
NCBI Accession #
NP_619579.1 [Other Products]
NCBI GenBank Nucleotide #
NM_138638.4 [Other Products]
UniProt Primary Accession #
Q549N0 [Other Products]
UniProt Related Accession #
Q549N0; Q9Y281[Other Products]
Molecular Weight
18,737 Da[Similar Products]
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NCBI Official Full Name
cofilin-2
NCBI Official Synonym Full Names
cofilin 2 (muscle)
NCBI Official Symbol
CFL2  [Similar Products]
NCBI Official Synonym Symbols
NEM7
  [Similar Products]
NCBI Protein Information
cofilin-2; OTTHUMP00000178805; OTTHUMP00000178806; cofilin, muscle isoform
UniProt Protein Name
Cofilin 2 (Muscle), isoform CRA_a
Protein Family
Cofilin
UniProt Gene Name
CFL2  [Similar Products]
UniProt Entry Name
Q549N0_HUMAN
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NCBI Summary for CFL2
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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UniProt Comments for CFL2
Cofilin-2: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.

Protein type: Cytoskeletal; Nuclear receptor co-regulator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: I band; extracellular space; nuclear matrix; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: muscle maintenance; actin filament depolymerization; positive regulation of actin filament depolymerization; sarcomere organization

Disease: Nemaline Myopathy 7
Research Articles on CFL2
1. PHD2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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