Full Product Name
ATG4C Antibody: RPE
Product Synonym Names
Rabbit Anti-Human ATG4C Polyclonal; AUT like 1cysteine endopeptidase (S. cerevisiae) Antibody; APG4 autophagy 4 homolog C Antibody; Cysteine protease ATG4C Antibody; APG4-C Antibody; Autophagy-related cysteine endopeptidase 3 Antibody; EC:3.4.22.- Antibody; ATG 4C Antibody; AUT like 1; cysteine endopeptidase Antibody; EC 3.4.22 Antibody; APG4C Antibody; Autophagin-3 Antibody; OTTHUMP00000010715 Antibody; AUTL3 Antibody; APG4 autophagy 4 homolog C (S. cerevisiae) Antibody; Autophagy related cysteine endopeptidase 3 Antibody; ATG4C Antibody; Autophagin 3 Antibody; ATG4 autophagy related 4 homolog C Antibody; AUT like 3 cysteine endopeptidase Antibody; AUTL1 Antibody; ATG4C_HUMAN Antibody; AUT (S. cerevisiae) like 1; cysteine endopeptidase Antibody; Autophagy-related protein 4 homolog C Antibody; Autophagy related protein 4 homolog C Antibody; ATG4 autophagy related 4 homolog C (S. cerevisiae) Antibody; Autophagy related 4C cysteine peptidase Antibody; Atg4c Antibody; APG4 C Antibody; FLJ14867 Antibody; AUT-like 3 cysteine endopeptidase Antibody
Product Gene Name
anti-ATG4C antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: ATG4C (MBS809598)
RPE Conjugated Antibody: ATG4C (MBS809614)
Matching Pairs
Unconjugated Antibody: N/A (MBS809614)
RPE Conjugated Antibody: ATG4C (MBS809614)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96DT6
Specificity
Detects ~50 kDa.
Purity/Purification
Peptide Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthetic peptide from the C-terminal of Human ATG4C (aa. 296-306)
Cellular Localization
Cytoplasm
Storage Buffer
PBS, 50% glycerol, 0.09% sodium azide
Tissue Specificity
Highly expressed in skeletal muscle, heart, liver and testis.
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-ATG4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ATG4C antibody
Antibodies; Cancer; Cardiovascular System; Autophagy
Applications Tested/Suitable for anti-ATG4C antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-ATG4C antibody
WB: 1:1000
ICC/IF: 1:100
Western Blot (WB) of anti-ATG4C antibody
Western blot analysis of Human Embryonic kidney epithelial cell line (HEK293T) lysate showing detection of 53 kDa ATG4C protein using Rabbit Anti-ATG4C Polyclonal Antibody (SPC-633). Lane 1: Molecular Weight Ladder (MW). Lane 2: Human HEK293T cell lysates. Load: 15 ug. Block: 2% GE Ashermsham in 1X TBST. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody (SPC-633) at 1:1000 for 16 hours at 4 degree C. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 minutes in RT. Predicted/Observed Size: 53 kDa.
NCBI/Uniprot data below describe general gene information for ATG4C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_116241.2
[Other Products]
NCBI GenBank Nucleotide #
NM_032852.3
[Other Products]
UniProt Primary Accession #
Q96DT6
[Other Products]
UniProt Secondary Accession #
Q96K04; A6NLR8; D3DQ58[Other Products]
UniProt Related Accession #
Q96DT6[Other Products]
Molecular Weight
52,497 Da
NCBI Official Full Name
cysteine protease ATG4C
NCBI Official Synonym Full Names
autophagy related 4C cysteine peptidase
NCBI Official Symbol
ATG4C [Similar Products]
NCBI Official Synonym Symbols
APG4C; AUTL1; AUTL3; APG4-C
[Similar Products]
NCBI Protein Information
cysteine protease ATG4C
UniProt Protein Name
Cysteine protease ATG4C
UniProt Synonym Protein Names
AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C
Protein Family
Cysteine protease
UniProt Gene Name
ATG4C [Similar Products]
UniProt Synonym Gene Names
APG4C; AUTL1; AUTL3 [Similar Products]
NCBI Summary for ATG4C
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ATG4C
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Research Articles on ATG4C
1. association between SNPs and Kashin-Beck disease
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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